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Global genetic analysis in mice unveils central role for cilia in congenital heart disease

Author

Listed:
  • You Li

    (University of Pittsburgh School of Medicine)

  • Nikolai T. Klena

    (University of Pittsburgh School of Medicine)

  • George C. Gabriel

    (University of Pittsburgh School of Medicine)

  • Xiaoqin Liu

    (University of Pittsburgh School of Medicine)

  • Andrew J. Kim

    (University of Pittsburgh School of Medicine)

  • Kristi Lemke

    (University of Pittsburgh School of Medicine)

  • Yu Chen

    (University of Pittsburgh School of Medicine)

  • Bishwanath Chatterjee

    (University of Pittsburgh School of Medicine)

  • William Devine

    (University of Pittsburgh School of Medicine)

  • Rama Rao Damerla

    (University of Pittsburgh School of Medicine)

  • Chienfu Chang

    (University of Pittsburgh School of Medicine)

  • Hisato Yagi

    (University of Pittsburgh School of Medicine)

  • Jovenal T. San Agustin

    (Program in Molecular Medicine, University of Massachusetts Medical School)

  • Mohamed Thahir

    (University of Pittsburgh School of Medicine
    Intelligent Systems Program, School of Arts and Sciences, University of Pittsburgh)

  • Shane Anderton

    (University of Pittsburgh School of Medicine)

  • Caroline Lawhead

    (University of Pittsburgh School of Medicine)

  • Anita Vescovi

    (University of Pittsburgh School of Medicine)

  • Herbert Pratt

    (The Jackson Laboratory)

  • Judy Morgan

    (The Jackson Laboratory)

  • Leslie Haynes

    (The Jackson Laboratory)

  • Cynthia L. Smith

    (The Jackson Laboratory)

  • Janan T. Eppig

    (The Jackson Laboratory)

  • Laura Reinholdt

    (The Jackson Laboratory)

  • Richard Francis

    (University of Pittsburgh School of Medicine)

  • Linda Leatherbury

    (The Heart Center, Children’s National Medical Center)

  • Madhavi K. Ganapathiraju

    (University of Pittsburgh School of Medicine
    Intelligent Systems Program, School of Arts and Sciences, University of Pittsburgh)

  • Kimimasa Tobita

    (University of Pittsburgh School of Medicine)

  • Gregory J. Pazour

    (Program in Molecular Medicine, University of Massachusetts Medical School)

  • Cecilia W. Lo

    (University of Pittsburgh School of Medicine)

Abstract

A forward genetic screen in fetal mice to identify genes involved in congenital heart disease (CHD) reveals that a large proportion of genes associated with CHD are related to cilia and cilia-transduced cell signalling, with potential implications for the human disease.

Suggested Citation

  • You Li & Nikolai T. Klena & George C. Gabriel & Xiaoqin Liu & Andrew J. Kim & Kristi Lemke & Yu Chen & Bishwanath Chatterjee & William Devine & Rama Rao Damerla & Chienfu Chang & Hisato Yagi & Jovenal, 2015. "Global genetic analysis in mice unveils central role for cilia in congenital heart disease," Nature, Nature, vol. 521(7553), pages 520-524, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7553:d:10.1038_nature14269
    DOI: 10.1038/nature14269
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    Citations

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    Cited by:

    1. Mark E. Becker & Laura Martin-Sancho & Lacy M. Simons & Michael D. McRaven & Sumit K. Chanda & Judd F. Hultquist & Thomas J. Hope, 2024. "Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Wei Feng & Abha Bais & Haoting He & Cassandra Rios & Shan Jiang & Juan Xu & Cindy Chang & Dennis Kostka & Guang Li, 2022. "Single-cell transcriptomic analysis identifies murine heart molecular features at embryonic and neonatal stages," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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