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The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

Author

Listed:
  • Colleen A. McHugh

    (California Institute of Technology)

  • Chun-Kan Chen

    (California Institute of Technology)

  • Amy Chow

    (California Institute of Technology)

  • Christine F. Surka

    (California Institute of Technology)

  • Christina Tran

    (California Institute of Technology)

  • Patrick McDonel

    (Broad Institute of MIT and Harvard)

  • Amy Pandya-Jones

    (Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California Los Angeles
    Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles)

  • Mario Blanco

    (California Institute of Technology)

  • Christina Burghard

    (California Institute of Technology)

  • Annie Moradian

    (Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology)

  • Michael J. Sweredoski

    (Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology)

  • Alexander A. Shishkin

    (California Institute of Technology)

  • Julia Su

    (California Institute of Technology)

  • Eric S. Lander

    (Broad Institute of MIT and Harvard)

  • Sonja Hess

    (Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology)

  • Kathrin Plath

    (Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California Los Angeles
    Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles)

  • Mitchell Guttman

    (California Institute of Technology)

Abstract

The mechanisms by which Xist, a long non-coding RNA, silences one X chromosome in female mammals are unknown; here a mass spectrometry-based approach is developed to identify several proteins that interact directly with Xist, including the transcriptional repressor SHARP that is required for transcriptional silencing through the histone deacetylase HDAC3.

Suggested Citation

  • Colleen A. McHugh & Chun-Kan Chen & Amy Chow & Christine F. Surka & Christina Tran & Patrick McDonel & Amy Pandya-Jones & Mario Blanco & Christina Burghard & Annie Moradian & Michael J. Sweredoski & A, 2015. "The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3," Nature, Nature, vol. 521(7551), pages 232-236, May.
    • Handle: RePEc:nat:nature:v:521:y:2015:i:7551:d:10.1038_nature14443
    DOI: 10.1038/nature14443
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    Citations

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    Cited by:

    1. Andrew Keniry & Natasha Jansz & Linden J. Gearing & Iromi Wanigasuriya & Joseph Chen & Christian M. Nefzger & Peter F. Hickey & Quentin Gouil & Joy Liu & Kelsey A. Breslin & Megan Iminitoff & Tamara B, 2022. "BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Lisa-Marie Appel & Vedran Franke & Johannes Benedum & Irina Grishkovskaya & Xué Strobl & Anton Polyansky & Gregor Ammann & Sebastian Platzer & Andrea Neudolt & Anna Wunder & Lena Walch & Stefanie Kais, 2023. "The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    3. Teresa Robert-Finestra & Beatrice F. Tan & Hegias Mira-Bontenbal & Erika Timmers & Cristina Gontan & Sarra Merzouk & Benedetto Daniele Giaimo & François Dossin & Wilfred F. J. IJcken & John W. M. Mart, 2021. "SPEN is required for Xist upregulation during initiation of X chromosome inactivation," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    4. Milan Kumar Samanta & Srimonta Gayen & Clair Harris & Emily Maclary & Yumie Murata-Nakamura & Rebecca M. Malcore & Robert S. Porter & Patricia M. Garay & Christina N. Vallianatos & Paul B. Samollow & , 2022. "Activation of Xist by an evolutionarily conserved function of KDM5C demethylase," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Marissa Cloutier & Surinder Kumar & Emily Buttigieg & Laura Keller & Brandon Lee & Aaron Williams & Sandra Mojica-Perez & Indri Erliandri & Andre Monteiro Da Rocha & Kenneth Cadigan & Gary D. Smith & , 2022. "Preventing erosion of X-chromosome inactivation in human embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    6. Lisa-Marie Appel & Vedran Franke & Melania Bruno & Irina Grishkovskaya & Aiste Kasiliauskaite & Tanja Kaufmann & Ursula E. Schoeberl & Martin G. Puchinger & Sebastian Kostrhon & Carmen Ebenwaldner & M, 2021. "PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC," Nature Communications, Nature, vol. 12(1), pages 1-24, December.

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