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Therapy-induced tumour secretomes promote resistance and tumour progression

Author

Listed:
  • Anna C. Obenauf

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center)

  • Yilong Zou

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
    Gerstner Sloan Kettering School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center)

  • Andrew L. Ji

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center)

  • Sakari Vanharanta

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
    MRC Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK)

  • Weiping Shu

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center)

  • Hubing Shi

    (University of California)

  • Xiangju Kong

    (University of California)

  • Marcus C. Bosenberg

    (Yale University School of Medicine
    Yale University School of Medicine)

  • Thomas Wiesner

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center)

  • Neal Rosen

    (Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center)

  • Roger S. Lo

    (University of California)

  • Joan Massagué

    (Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center)

Abstract

Tumour cells respond to an effective, targeted drug treatment with BRAF, ALK or EGFR kinase inhibitors by inducing a complex network of secreted signals that promote tumour growth, dissemination and metastasis of drug-resistant cancer cell clones, and increase the survival of drug-sensitive tumour cells, potentially contributing to incomplete tumour regression.

Suggested Citation

  • Anna C. Obenauf & Yilong Zou & Andrew L. Ji & Sakari Vanharanta & Weiping Shu & Hubing Shi & Xiangju Kong & Marcus C. Bosenberg & Thomas Wiesner & Neal Rosen & Roger S. Lo & Joan Massagué, 2015. "Therapy-induced tumour secretomes promote resistance and tumour progression," Nature, Nature, vol. 520(7547), pages 368-372, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7547:d:10.1038_nature14336
    DOI: 10.1038/nature14336
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    Cited by:

    1. Josefine Radke & Elisa Schumann & Julia Onken & Randi Koll & Güliz Acker & Bohdan Bodnar & Carolin Senger & Sascha Tierling & Markus Möbs & Peter Vajkoczy & Anna Vidal & Sandra Högler & Petra Kodajova, 2022. "Decoding molecular programs in melanoma brain metastases," Nature Communications, Nature, vol. 13(1), pages 1-24, December.
    2. David Gonzalez-Martinez & Lee Roth & Thomas R. Mumford & Juan Guan & Anh Le & Robert C. Doebele & Bo Huang & Asmin Tulpule & Magdalena Niewiadomska-Bugaj & Trever G. Bivona & Lukasz J. Bugaj, 2024. "Oncogenic EML4-ALK assemblies suppress growth factor perception and modulate drug tolerance," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Victoria O. Shender & Ksenia S. Anufrieva & Polina V. Shnaider & Georgij P. Arapidi & Marat S. Pavlyukov & Olga M. Ivanova & Irina K. Malyants & Grigory A. Stepanov & Evgenii Zhuravlev & Rustam H. Zig, 2024. "Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells," Nature Communications, Nature, vol. 15(1), pages 1-26, December.

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