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Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Author

Listed:
  • Christina Twyman-Saint Victor

    (Perelman School of Medicine, University of Pennsylvania
    Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania)

  • Andrew J. Rech

    (Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania)

  • Amit Maity

    (Perelman School of Medicine, University of Pennsylvania
    Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania)

  • Ramesh Rengan

    (Perelman School of Medicine, University of Pennsylvania
    Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
    Present addresses: Department of Radiation Oncology, University of Washington School of Medicine, Washington 98195, USA (R.R.); Division of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (S.M.H.).)

  • Kristen E. Pauken

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Erietta Stelekati

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Joseph L. Benci

    (Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Bihui Xu

    (Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Hannah Dada

    (Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Pamela M. Odorizzi

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Ramin S. Herati

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Kathleen D. Mansfield

    (Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Dana Patsch

    (Perelman School of Medicine, University of Pennsylvania)

  • Ravi K. Amaravadi

    (Perelman School of Medicine, University of Pennsylvania
    Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania)

  • Lynn M. Schuchter

    (Perelman School of Medicine, University of Pennsylvania
    Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania)

  • Hemant Ishwaran

    (University of Miami)

  • Rosemarie Mick

    (Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Daniel A. Pryma

    (Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Xiaowei Xu

    (Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Michael D. Feldman

    (Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania)

  • Tara C. Gangadhar

    (Perelman School of Medicine, University of Pennsylvania
    Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania)

  • Stephen M. Hahn

    (Perelman School of Medicine, University of Pennsylvania
    Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
    Present addresses: Department of Radiation Oncology, University of Washington School of Medicine, Washington 98195, USA (R.R.); Division of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA (S.M.H.).)

  • E. John Wherry

    (Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Robert H. Vonderheide

    (Perelman School of Medicine, University of Pennsylvania
    Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania
    Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

  • Andy J. Minn

    (Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania
    Perelman School of Medicine, University of Pennsylvania
    Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
    Institute for Immunology, Perelman School of Medicine, University of Pennsylvania)

Abstract

In this study, involving melanoma patients and a mouse model for melanoma, an optimal anti-tumour response was induced by using a combination of radiation with anti-CTLA4 and anti-PD-L1 antibody therapies, each attacking the tumour from a different angle.

Suggested Citation

  • Christina Twyman-Saint Victor & Andrew J. Rech & Amit Maity & Ramesh Rengan & Kristen E. Pauken & Erietta Stelekati & Joseph L. Benci & Bihui Xu & Hannah Dada & Pamela M. Odorizzi & Ramin S. Herati & , 2015. "Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer," Nature, Nature, vol. 520(7547), pages 373-377, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7547:d:10.1038_nature14292
    DOI: 10.1038/nature14292
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    Cited by:

    1. Jun Jiang & Lili Yang & Qianqian Xie & Xi Liu & Jie Jiang & Jie Zhang & Shuping Zhang & Huizhen Zheng & Wenjie Li & Xiaoming Cai & Sijin Liu & Ruibin Li, 2024. "Synthetic vectors for activating the driving axis of ferroptosis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Ying Zhang & Raghava N. Sriramaneni & Paul A. Clark & Justin C. Jagodinsky & Mingzhou Ye & Wonjong Jin & Yuyuan Wang & Amber Bates & Caroline P. Kerr & Trang Le & Raad Allawi & Xiuxiu Wang & Ruosen Xi, 2022. "Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Qiuyue Wu & Wencheng Wang & Chi Zhang & Zhenlong You & Yinyan Zeng & Yinzhu Lu & Suhui Zhang & Xingrui Li & Chaoyong Yang & Yanling Song, 2023. "Capturing nascent extracellular vesicles by metabolic glycan labeling-assisted microfluidics," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    4. Nils-Petter Rudqvist & Maud Charpentier & Claire Lhuillier & Erik Wennerberg & Sheila Spada & Caroline Sheridan & Xi Kathy Zhou & Tuo Zhang & Silvia C. Formenti & Jennifer S. Sims & Alicia Alonso & Sa, 2023. "Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumors," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    5. Caroline S. Jansen & Meghana S. Pagadala & Maria A. Cardenas & Roshan S. Prabhu & Subir Goyal & Chengjing Zhou & Prasanthi Chappa & BaoHan T. Vo & Chengyu Ye & Benjamin Hopkins & Jim Zhong & Adam Klie, 2024. "Pre-operative stereotactic radiosurgery and peri-operative dexamethasone for resectable brain metastases: a two-arm pilot study evaluating clinical outcomes and immunological correlates," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Irma Telarovic & Carmen S. M. Yong & Lisa Kurz & Irene Vetrugno & Sabrina Reichl & Alba Sanchez Fernandez & Hung-Wei Cheng & Rona Winkler & Matthias Guckenberger & Anja Kipar & Burkhard Ludewig & Mart, 2024. "Delayed tumor-draining lymph node irradiation preserves the efficacy of combined radiotherapy and immune checkpoint blockade in models of metastatic disease," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    7. David J. Klinke & Audry Fernandez & Wentao Deng & Atefeh Razazan & Habibolla Latifizadeh & Anika C. Pirkey, 2022. "Data-driven learning how oncogenic gene expression locally alters heterocellular networks," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    8. Mao, Xiaojun & Peng, Liuhua & Wang, Zhonglei, 2022. "Nonparametric feature selection by random forests and deep neural networks," Computational Statistics & Data Analysis, Elsevier, vol. 170(C).
    9. Xin Guan & Liping Sun & Yuting Shen & Fengshan Jin & Xiaowan Bo & Chunyan Zhu & Xiaoxia Han & Xiaolong Li & Yu Chen & Huixiong Xu & Wenwen Yue, 2022. "Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    10. Lin-Zhou Zhang & Jie-Gang Yang & Gai-Li Chen & Qi-Hui Xie & Qiu-Yun Fu & Hou-Fu Xia & Yi-Cun Li & Jue Huang & Ye Li & Min Wu & Hai-Ming Liu & Fu-Bing Wang & Ke-Zhen Yi & Huan-Gang Jiang & Fu-Xiang Zho, 2024. "PD-1/CD80+ small extracellular vesicles from immunocytes induce cold tumours featured with enhanced adaptive immunosuppression," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    11. Eiran Z Gorodeski & Emer Joyce & Benjamin T Gandesbery & Eugene H Blackstone & David O Taylor & W H Wilson Tang & Randall C Starling & Rory Hachamovitch, 2017. "Discordance between 'actual' and 'scheduled' check-in times at a heart failure clinic," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-13, November.
    12. Li, Qian & Xiao, Yanni, 2019. "Bifurcation analyses and hormetic effects of a discrete-time tumor model," Applied Mathematics and Computation, Elsevier, vol. 363(C), pages 1-1.
    13. Dina V. Hingorani & Michael M. Allevato & Maria F. Camargo & Jacqueline Lesperance & Maryam A. Quraishi & Joseph Aguilera & Ida Franiak-Pietryga & Daniel J. Scanderbeg & Zhiyong Wang & Alfredo A. Moli, 2022. "Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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