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Recognition determinants of broadly neutralizing human antibodies against dengue viruses

Author

Listed:
  • Alexander Rouvinski

    (Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
    CNRS UMR 3569 Virologie, 75724 Paris Cedex 15, France)

  • Pablo Guardado-Calvo

    (Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
    CNRS UMR 3569 Virologie, 75724 Paris Cedex 15, France)

  • Giovanna Barba-Spaeth

    (Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
    CNRS UMR 3569 Virologie, 75724 Paris Cedex 15, France)

  • Stéphane Duquerroy

    (Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
    CNRS UMR 3569 Virologie, 75724 Paris Cedex 15, France
    Université Paris-Sud, Faculté des Sciences, 91405 Orsay, France)

  • Marie-Christine Vaney

    (Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
    CNRS UMR 3569 Virologie, 75724 Paris Cedex 15, France)

  • Carlos M. Kikuti

    (Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
    CNRS UMR 3569 Virologie, 75724 Paris Cedex 15, France
    Present addresses: Institut Curie, 75248 Paris Cedex 05, France (C.M.K.); Altravax, Inc., 725 San Aleso Avenue, Suite 2, Sunnyvale, California 94085, USA (M.E.N.S.); U1157 INSERM GIP-CYROI, 97491 Saint Clotilde, La Réunion, France (P.De.); Institut Pasteur du Cambodge, 5 Monivong Boulevard, PO Box 983, Phnom Penh, Cambodia (P.Du.).)

  • M. Erika Navarro Sanchez

    (Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
    CNRS UMR 3569 Virologie, 75724 Paris Cedex 15, France
    Present addresses: Institut Curie, 75248 Paris Cedex 05, France (C.M.K.); Altravax, Inc., 725 San Aleso Avenue, Suite 2, Sunnyvale, California 94085, USA (M.E.N.S.); U1157 INSERM GIP-CYROI, 97491 Saint Clotilde, La Réunion, France (P.De.); Institut Pasteur du Cambodge, 5 Monivong Boulevard, PO Box 983, Phnom Penh, Cambodia (P.Du.).)

  • Wanwisa Dejnirattisai

    (Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK)

  • Wiyada Wongwiwat

    (Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK)

  • Ahmed Haouz

    (Institut Pasteur, Protéopôle, CNRS UMR 3528, 75724 Paris Cedex 15, France)

  • Christine Girard-Blanc

    (Institut Pasteur, Protéopôle, CNRS UMR 3528, 75724 Paris Cedex 15, France)

  • Stéphane Petres

    (Institut Pasteur, Protéopôle, CNRS UMR 3528, 75724 Paris Cedex 15, France)

  • William E. Shepard

    (Synchrotron SOLEIL, L’Orme des Merisiers, Saint Aubin, BP48, 91192 Gif-sur-Yvette, France)

  • Philippe Desprès

    (Institut Pasteur, Unité des Interactions Moléculaires Flavivirus-Hôtes, 75724 Paris Cedex 15, France
    Present addresses: Institut Curie, 75248 Paris Cedex 05, France (C.M.K.); Altravax, Inc., 725 San Aleso Avenue, Suite 2, Sunnyvale, California 94085, USA (M.E.N.S.); U1157 INSERM GIP-CYROI, 97491 Saint Clotilde, La Réunion, France (P.De.); Institut Pasteur du Cambodge, 5 Monivong Boulevard, PO Box 983, Phnom Penh, Cambodia (P.Du.).)

  • Fernando Arenzana-Seisdedos

    (Institut Pasteur, Unité de Pathogénie Virale, INSERM U1108, 75724 Paris Cedex 15, France)

  • Philippe Dussart

    (Institut Pasteur de Guyane, BP 6010, 97306 Cayenne, French Guiana
    Present addresses: Institut Curie, 75248 Paris Cedex 05, France (C.M.K.); Altravax, Inc., 725 San Aleso Avenue, Suite 2, Sunnyvale, California 94085, USA (M.E.N.S.); U1157 INSERM GIP-CYROI, 97491 Saint Clotilde, La Réunion, France (P.De.); Institut Pasteur du Cambodge, 5 Monivong Boulevard, PO Box 983, Phnom Penh, Cambodia (P.Du.).)

  • Juthathip Mongkolsapaya

    (Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK
    Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand)

  • Gavin R. Screaton

    (Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK)

  • Félix A. Rey

    (Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
    CNRS UMR 3569 Virologie, 75724 Paris Cedex 15, France
    Institut Pasteur, Protéopôle, CNRS UMR 3528, 75724 Paris Cedex 15, France)

Abstract

Human antibodies in complex with the soluble dimeric form of the dengue virus envelope protein E recognize a quaternary epitope and exhibit strong neutralizing activity against all four virus serotypes.

Suggested Citation

  • Alexander Rouvinski & Pablo Guardado-Calvo & Giovanna Barba-Spaeth & Stéphane Duquerroy & Marie-Christine Vaney & Carlos M. Kikuti & M. Erika Navarro Sanchez & Wanwisa Dejnirattisai & Wiyada Wongwiwat, 2015. "Recognition determinants of broadly neutralizing human antibodies against dengue viruses," Nature, Nature, vol. 520(7545), pages 109-113, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7545:d:10.1038_nature14130
    DOI: 10.1038/nature14130
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    Cited by:

    1. Antonio Santos-Peral & Fabian Luppa & Sebastian Goresch & Elena Nikolova & Magdalena Zaucha & Lisa Lehmann & Frank Dahlstroem & Hadi Karimzadeh & Julia Thorn-Seshold & Elena Winheim & Ev-Marie Schuste, 2024. "Prior flavivirus immunity skews the yellow fever vaccine response to cross-reactive antibodies with potential to enhance dengue virus infection," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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