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G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

Author

Listed:
  • Masoud Ghamari-Langroudi

    (Vanderbilt University Medical Center)

  • Gregory J. Digby

    (Vanderbilt University Medical Center)

  • Julien A. Sebag

    (Vanderbilt University Medical Center)

  • Glenn L. Millhauser

    (University of California)

  • Rafael Palomino

    (University of California)

  • Robert Matthews

    (Vanderbilt University Medical Center)

  • Taneisha Gillyard

    (Vanderbilt University Medical Center
    Meharry Medical College)

  • Brandon L. Panaro

    (Vanderbilt University Medical Center)

  • Iain R. Tough

    (King’s College London, Wolfson Centre for Age-Related Diseases, Guy’s Campus, London SE1 1UL, UK)

  • Helen M. Cox

    (King’s College London, Wolfson Centre for Age-Related Diseases, Guy’s Campus, London SE1 1UL, UK)

  • Jerod S. Denton

    (Vanderbilt University Medical Center
    Vanderbilt University Medical Center)

  • Roger D. Cone

    (Vanderbilt University Medical Center)

Abstract

α-MSH and AgRP, two hypothalamus-derived peptides with opposing actions on the melanocortin-4 receptor (MC4R), modulate neurons driving feeding behaviour; although previous downstream mechanisms of cellular modulation by these peptides have been determined, here α-MSH and AgRP are shown to regulate neural activity by coupling MC4R to Kir7.1 potassium channels and closing or opening them, respectively.

Suggested Citation

  • Masoud Ghamari-Langroudi & Gregory J. Digby & Julien A. Sebag & Glenn L. Millhauser & Rafael Palomino & Robert Matthews & Taneisha Gillyard & Brandon L. Panaro & Iain R. Tough & Helen M. Cox & Jerod S, 2015. "G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons," Nature, Nature, vol. 520(7545), pages 94-98, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7545:d:10.1038_nature14051
    DOI: 10.1038/nature14051
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    Cited by:

    1. Thomas Fontaine & Andreas Busch & Toon Laeremans & Stéphane De Cesco & Yi-Lynn Liang & Veli-Pekka Jaakola & Zara Sands & Sarah Triest & Simonas Masiulis & Lies Dekeyzer & Noor Samyn & Nicolas Loeys & , 2024. "Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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