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Catalysts from synthetic genetic polymers

Author

Listed:
  • Alexander I. Taylor

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK)

  • Vitor B. Pinheiro

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK
    Present address: Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK, and Structural and Molecular Biology Department, University College London, Gower Street, London WC1E 6BT, UK.)

  • Matthew J. Smola

    (University of North Carolina)

  • Alexey S. Morgunov

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK)

  • Sew Peak-Chew

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK)

  • Christopher Cozens

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK)

  • Kevin M. Weeks

    (University of North Carolina)

  • Piet Herdewijn

    (KU Leuven, Rega Institute, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Université Evry, Institute of Systems and Synthetic Biology, 5 rue Henri Desbruères, 91030 Evry Cedex, France)

  • Philipp Holliger

    (MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK)

Abstract

Four different XNAs — polymers with backbone chemistries not found in nature, namely, arabino nucleic acids, 2′-fluoroarabino nucleic acids, hexitol nucleic acids and cyclohexene nucleic acids — are found to be able to support the evolution of synthetic enzymes (XNAzymes) that catalyse several chemical reactions.

Suggested Citation

  • Alexander I. Taylor & Vitor B. Pinheiro & Matthew J. Smola & Alexey S. Morgunov & Sew Peak-Chew & Christopher Cozens & Kevin M. Weeks & Piet Herdewijn & Philipp Holliger, 2015. "Catalysts from synthetic genetic polymers," Nature, Nature, vol. 518(7539), pages 427-430, February.
    • Handle: RePEc:nat:nature:v:518:y:2015:i:7539:d:10.1038_nature13982
    DOI: 10.1038/nature13982
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    Cited by:

    1. Pehuén Pereyra Gerber & Maria J. Donde & Nicholas J. Matheson & Alexander I. Taylor, 2022. "XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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