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Optogenetic control of organelle transport and positioning

Author

Listed:
  • Petra van Bergeijk

    (Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands)

  • Max Adrian

    (Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands)

  • Casper C. Hoogenraad

    (Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands)

  • Lukas C. Kapitein

    (Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands)

Abstract

An optogenetic strategy allowing light-mediated recruitment of distinct cytoskeletal motor proteins to specific organelles is established; this technique enabled rapid and reversible activation or inhibition of the transport of organelles such as peroxisomes, recycling endosomes and mitochondria with high spatiotemporal accuracy, and the approach was also applied to primary neurons to demonstrate optical control of axonal growth by recycling endosome repositioning.

Suggested Citation

  • Petra van Bergeijk & Max Adrian & Casper C. Hoogenraad & Lukas C. Kapitein, 2015. "Optogenetic control of organelle transport and positioning," Nature, Nature, vol. 518(7537), pages 111-114, February.
    • Handle: RePEc:nat:nature:v:518:y:2015:i:7537:d:10.1038_nature14128
    DOI: 10.1038/nature14128
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    Cited by:

    1. Xiaofeng Sun & Chengjian Zhou & Simin Xia & Xi Chen, 2023. "Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Ana Fernandez-Nicolas & Alicia Uchida & Jessica Poon & Mamiko Yajima, 2022. "Vasa nucleates asymmetric translation along the mitotic spindle during unequal cell divisions," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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