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Reproducibility: Standardize antibodies used in research

Author

Listed:
  • Andrew Bradbury

    (Los Alamos National Laboratory, Los Alamos, New Mexico, USA.)

  • Andreas Plückthun

    (Switzerland.)

Abstract

To save millions of dollars and dramatically improve reproducibility, protein-binding reagents must be defined by their sequences and produced as recombinant proteins, say Andrew Bradbury, Andreas Plückthun and 110 co-signatories.

Suggested Citation

  • Andrew Bradbury & Andreas Plückthun, 2015. "Reproducibility: Standardize antibodies used in research," Nature, Nature, vol. 518(7537), pages 27-29, February.
  • Handle: RePEc:nat:nature:v:518:y:2015:i:7537:d:10.1038_518027a
    DOI: 10.1038/518027a
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    Cited by:

    1. Susanne Prokop & Péter Ábrányi-Balogh & Benjámin Barti & Márton Vámosi & Miklós Zöldi & László Barna & Gabriella M. Urbán & András Dávid Tóth & Barna Dudok & Attila Egyed & Hui Deng & Gian Marco Leggi, 2021. "PharmacoSTORM nanoscale pharmacology reveals cariprazine binding on Islands of Calleja granule cells," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    2. Edward P. Harvey & Jung-Eun Shin & Meredith A. Skiba & Genevieve R. Nemeth & Joseph D. Hurley & Alon Wellner & Ada Y. Shaw & Victor G. Miranda & Joseph K. Min & Chang C. Liu & Debora S. Marks & Andrew, 2022. "An in silico method to assess antibody fragment polyreactivity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Linsley Kelly & Keith E. Maier & Amy Yan & Matthew Levy, 2021. "A comparative analysis of cell surface targeting aptamers," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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