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The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C

Author

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  • Daisuke Izawa

    (Tennis Court Road, Cambridge CB2 1QN, UK)

  • Jonathon Pines

    (Tennis Court Road, Cambridge CB2 1QN, UK)

Abstract

By binding and inhibiting a second CDC20 molecule, the mitotic checkpoint complex can convert a local ‘wait’ signal from unattached kinetochores to inhibit the anaphase promoting complex/cyclosome throughout the cell and avoid premature cell division.

Suggested Citation

  • Daisuke Izawa & Jonathon Pines, 2015. "The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C," Nature, Nature, vol. 517(7536), pages 631-634, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7536:d:10.1038_nature13911
    DOI: 10.1038/nature13911
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    Cited by:

    1. Elyse S. Fischer & Conny W. H. Yu & Johannes F. Hevler & Stephen H. McLaughlin & Sarah L. Maslen & Albert J. R. Heck & Stefan M. V. Freund & David Barford, 2022. "Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Fridolin Gross & Paolo Bonaiuti & Silke Hauf & Andrea Ciliberto, 2018. "Implications of alternative routes to APC/C inhibition by the mitotic checkpoint complex," PLOS Computational Biology, Public Library of Science, vol. 14(9), pages 1-19, September.

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