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Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB

Author

Listed:
  • Manuel A. Ortega

    (University of Illinois at Urbana–Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA)

  • Yue Hao

    (University of Illinois at Urbana–Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA)

  • Qi Zhang

    (University of Illinois at Urbana–Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA)

  • Mark C. Walker

    (University of Illinois at Urbana–Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA)

  • Wilfred A. van der Donk

    (University of Illinois at Urbana–Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    University of Illinois at Urbana–Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA)

  • Satish K. Nair

    (University of Illinois at Urbana–Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    Center for Biophysics and Computational Biology, University of Illinois at Urbana–Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA)

Abstract

Structural and biochemical studies show that the biosynthesis of the food preservative nisin involves the tRNA-dependent glutamylation of serine and threonine.

Suggested Citation

  • Manuel A. Ortega & Yue Hao & Qi Zhang & Mark C. Walker & Wilfred A. van der Donk & Satish K. Nair, 2015. "Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB," Nature, Nature, vol. 517(7535), pages 509-512, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7535:d:10.1038_nature13888
    DOI: 10.1038/nature13888
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    Cited by:

    1. Shan Wang & Sixing Lin & Qing Fang & Roland Gyampoh & Zhou Lu & Yingli Gao & David J. Clarke & Kewen Wu & Laurent Trembleau & Yi Yu & Kwaku Kyeremeh & Bruce F. Milne & Jioji Tabudravu & Hai Deng, 2022. "A ribosomally synthesised and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motif," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Dan Xue & Ethan A. Older & Zheng Zhong & Zhuo Shang & Nanzhu Chen & Nolan Dittenhauser & Lukuan Hou & Peiyan Cai & Michael D. Walla & Shi-Hui Dong & Xiaoyu Tang & Hexin Chen & Prakash Nagarkatti & Mit, 2022. "Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Richard S. Ayikpoe & Chengyou Shi & Alexander J. Battiste & Sara M. Eslami & Sangeetha Ramesh & Max A. Simon & Ian R. Bothwell & Hyunji Lee & Andrew J. Rice & Hengqian Ren & Qiqi Tian & Lonnie A. Harr, 2022. "A scalable platform to discover antimicrobials of ribosomal origin," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Yifan Li & Kai Shao & Zhaoxing Li & Kongfu Zhu & Bee Koon Gan & Jian Shi & Yibei Xiao & Min Luo, 2024. "Mechanistic insights into lanthipeptide modification by a distinct subclass of LanKC enzyme that forms dimers," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    5. Nguyet A. Nguyen & F. N. U. Vidya & Neela H. Yennawar & Hongwei Wu & Andrew C. McShan & Vinayak Agarwal, 2024. "Disordered regions in proteusin peptides guide post-translational modification by a flavin-dependent RiPP brominase," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Wan-Qiu Liu & Xiangyang Ji & Fang Ba & Yufei Zhang & Huiling Xu & Shuhui Huang & Xiao Zheng & Yifan Liu & Shengjie Ling & Michael C. Jewett & Jian Li, 2024. "Cell-free biosynthesis and engineering of ribosomally synthesized lanthipeptides," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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