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Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

Author

Listed:
  • Mark W. Pellegrino

    (Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Amrita M. Nargund

    (Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Natalia V. Kirienko

    (Massachusetts General Hospital
    Harvard Medical School)

  • Reba Gillis

    (Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA)

  • Christopher J. Fiorese

    (BCMB Allied Program, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA)

  • Cole M. Haynes

    (Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    BCMB Allied Program, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA)

Abstract

A link between an intracellular stress response, bacterial infection and triggering of the innate immune response is shown in Caenorhabditis elegans; exposure to the pathogen Pseudomonas aeruginosa caused activation of the transcription factor ATFS-1 and innate immunity that is regulated by the mitochondrial unfolded protein response.

Suggested Citation

  • Mark W. Pellegrino & Amrita M. Nargund & Natalia V. Kirienko & Reba Gillis & Christopher J. Fiorese & Cole M. Haynes, 2014. "Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection," Nature, Nature, vol. 516(7531), pages 414-417, December.
    • Handle: RePEc:nat:nature:v:516:y:2014:i:7531:d:10.1038_nature13818
    DOI: 10.1038/nature13818
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    Cited by:

    1. Eunah Kim & Andrea Annibal & Yujin Lee & Hae-Eun H. Park & Seokjin Ham & Dae-Eun Jeong & Younghun Kim & Sangsoon Park & Sujeong Kwon & Yoonji Jung & JiSoo Park & Sieun S. Kim & Adam Antebi & Seung-Jae, 2023. "Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Liankui Zhou & Liu Jiang & Lan Li & Chengchuan Ma & Peixue Xia & Wanqiu Ding & Ying Liu, 2024. "A germline-to-soma signal triggers an age-related decline of mitochondrial stress response," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Zihao Wang & Qian Zhang & Yayun Jiang & Jun Zhou & Ye Tian, 2024. "ASI-RIM neuronal axis regulates systemic mitochondrial stress response via TGF-β signaling cascade," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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