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MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

Author

Listed:
  • Thomas Powles

    (Barts Cancer Institute, Queen Mary University of London, Barts Experimental Cancer Medicine Centre, London EC1M 6BQ, UK)

  • Joseph Paul Eder

    (Yale Cancer Center, 333 Cedar Street, WWW211, New Haven, Connecticut 06520, USA)

  • Gregg D. Fine

    (Genentech, Inc. 1 DNA Way)

  • Fadi S. Braiteh

    (Comprehensive Cancer Centers of Nevada, 3730 S. Eastern Avenue)

  • Yohann Loriot

    (Gustave Roussy, 114 Rue Édouard Vaillant, 94805 Villejuif, France)

  • Cristina Cruz

    (Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital. Passeig Vall d’Hebron, 119-129, 08035, Barcelona, Spain)

  • Joaquim Bellmunt

    (Bladder Cancer Center, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, 450 Brookline Avenue, Boston, Massachusetts 02215, USA)

  • Howard A. Burris

    (Sarah Cannon Research Institute, 3322 West End Avenue, Suite 900, Nashville, Tennessee 37203, USA)

  • Daniel P. Petrylak

    (Yale Cancer Center, 333 Cedar Street, WWW211, New Haven, Connecticut 06520, USA)

  • Siew-leng Teng

    (Genentech, Inc. 1 DNA Way)

  • Xiaodong Shen

    (Genentech, Inc. 1 DNA Way)

  • Zachary Boyd

    (Genentech, Inc. 1 DNA Way)

  • Priti S. Hegde

    (Genentech, Inc. 1 DNA Way)

  • Daniel S. Chen

    (Genentech, Inc. 1 DNA Way)

  • Nicholas J. Vogelzang

    (University of Nevada School of Medicine and US Oncology/Comprehensive Cancer Centers of Nevada, 3730 S. Eastern Avenue)

Abstract

The results of a clinical phase I study in metastatic urothelial bladder cancer treated with the MPDL3280A antibody show that expression of PD-L1 on tumour-infiltrating immune cells is relevant for the therapeutic response.

Suggested Citation

  • Thomas Powles & Joseph Paul Eder & Gregg D. Fine & Fadi S. Braiteh & Yohann Loriot & Cristina Cruz & Joaquim Bellmunt & Howard A. Burris & Daniel P. Petrylak & Siew-leng Teng & Xiaodong Shen & Zachary, 2014. "MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer," Nature, Nature, vol. 515(7528), pages 558-562, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7528:d:10.1038_nature13904
    DOI: 10.1038/nature13904
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    Cited by:

    1. Stefanie Hiltbrunner & Lena Cords & Sabrina Kasser & Sandra N. Freiberger & Susanne Kreutzer & Nora C. Toussaint & Linda Grob & Isabelle Opitz & Michael Messerli & Martin Zoche & Alex Soltermann & Mar, 2023. "Acquired resistance to anti-PD1 therapy in patients with NSCLC associates with immunosuppressive T cell phenotype," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Magdalena Zajac & Jiabu Ye & Pralay Mukhopadhyay & Xiaoping Jin & Yong Ben & Joyce Antal & Ashok K Gupta & Marlon C Rebelatto & J Andrew Williams & Jill Walker, 2020. "Optimal PD-L1–high cutoff for association with overall survival in patients with urothelial cancer treated with durvalumab monotherapy," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-14, April.
    3. Yu-Ting Yen & May Chien & Pei-Yi Wu & Chi-Chang Ho & Chun-Te Ho & Kevin Chih-Yang Huang & Shu-Fen Chiang & K. S. Clifford Chao & William Tzu-Liang Chen & Shih-Chieh Hung, 2021. "Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    4. Omar Alhalabi & Jianfeng Chen & Yuxue Zhang & Yang Lu & Qi Wang & Sumankalai Ramachandran & Rebecca Slack Tidwell & Guangchun Han & Xinmiao Yan & Jieru Meng & Ruiping Wang & Anh G. Hoang & Wei-Lien Wa, 2022. "MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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