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Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells

Author

Listed:
  • Thomas M. Carlile

    (Massachusetts Institute of Technology)

  • Maria F. Rojas-Duran

    (Massachusetts Institute of Technology)

  • Boris Zinshteyn

    (Massachusetts Institute of Technology)

  • Hakyung Shin

    (Massachusetts Institute of Technology)

  • Kristen M. Bartoli

    (Massachusetts Institute of Technology)

  • Wendy V. Gilbert

    (Massachusetts Institute of Technology)

Abstract

The modification of uridine to pseudouridine is widespread in transfer and ribosomal RNAs but not observed so far in a coding RNA; here a new technique is used to detect this modification on a genome-wide scale, leading to the identification of pseudouridylation in messenger RNAs as well as almost 100 new sites in non-coding RNAs.

Suggested Citation

  • Thomas M. Carlile & Maria F. Rojas-Duran & Boris Zinshteyn & Hakyung Shin & Kristen M. Bartoli & Wendy V. Gilbert, 2014. "Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells," Nature, Nature, vol. 515(7525), pages 143-146, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7525:d:10.1038_nature13802
    DOI: 10.1038/nature13802
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    Cited by:

    1. Abu Zahid Bin Aziz & Md Al Mehedi Hasan & Jungpil Shin, 2021. "Identification of RNA pseudouridine sites using deep learning approaches," PLOS ONE, Public Library of Science, vol. 16(2), pages 1-13, February.
    2. Elzbieta Kierzek & Xiaoju Zhang & Richard M. Watson & Scott D. Kennedy & Marta Szabat & Ryszard Kierzek & David H. Mathews, 2022. "Secondary structure prediction for RNA sequences including N6-methyladenosine," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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