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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Author

Listed:
  • Andrea Viale

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Piergiorgio Pettazzoni

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Costas A. Lyssiotis

    (Weill Cornell Medical College)

  • Haoqiang Ying

    (The University of Texas MD Anderson Cancer Center)

  • Nora Sánchez

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Matteo Marchesini

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Alessandro Carugo

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center
    European Institute of Oncology, Milan 20139, Italy)

  • Tessa Green

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Sahil Seth

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Virginia Giuliani

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Maria Kost-Alimova

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Florian Muller

    (The University of Texas MD Anderson Cancer Center)

  • Simona Colla

    (The University of Texas MD Anderson Cancer Center)

  • Luigi Nezi

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Giannicola Genovese

    (The University of Texas MD Anderson Cancer Center)

  • Angela K. Deem

    (The University of Texas MD Anderson Cancer Center)

  • Avnish Kapoor

    (The University of Texas MD Anderson Cancer Center)

  • Wantong Yao

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Emanuela Brunetto

    (Pathology Unit, San Raffaele Scientific Institute, Milan 20132, Italy)

  • Ya’an Kang

    (The University of Texas MD Anderson Cancer Center)

  • Min Yuan

    (Beth Israel Deaconess Medical Center)

  • John M. Asara

    (Beth Israel Deaconess Medical Center)

  • Y. Alan Wang

    (The University of Texas MD Anderson Cancer Center)

  • Timothy P. Heffernan

    (Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center)

  • Alec C. Kimmelman

    (Dana-Farber Cancer Institute)

  • Huamin Wang

    (The University of Texas MD Anderson Cancer Center)

  • Jason B. Fleming

    (The University of Texas MD Anderson Cancer Center)

  • Lewis C. Cantley

    (Weill Cornell Medical College)

  • Ronald A. DePinho

    (The University of Texas MD Anderson Cancer Center)

  • Giulio F. Draetta

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

Abstract

KRAS mutations are a driver event of pancreatic ductal adenocarcinoma; here, a subpopulation of dormant tumour cells, relying on oxidative phosphorylation for survival, is shown to be responsible for tumour relapse after treatment targeting the KRAS pathway.

Suggested Citation

  • Andrea Viale & Piergiorgio Pettazzoni & Costas A. Lyssiotis & Haoqiang Ying & Nora Sánchez & Matteo Marchesini & Alessandro Carugo & Tessa Green & Sahil Seth & Virginia Giuliani & Maria Kost-Alimova &, 2014. "Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function," Nature, Nature, vol. 514(7524), pages 628-632, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7524:d:10.1038_nature13611
    DOI: 10.1038/nature13611
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    Cited by:

    1. Shuaifeng Li & Shixun Han & Qi Zhang & Yibing Zhu & Haitao Zhang & Junli Wang & Yang Zhao & Jianhui Zhao & Lin Su & Li Li & Dawang Zhou & Cunqi Ye & Xin-Hua Feng & Tingbo Liang & Bin Zhao, 2022. "FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Sarah Figarol & Célia Delahaye & Rémi Gence & Aurélia Doussine & Juan Pablo Cerapio & Mathylda Brachais & Claudine Tardy & Nicolas Béry & Raghda Asslan & Jacques Colinge & Jean-Philippe Villemin & Ant, 2024. "Farnesyltransferase inhibition overcomes oncogene-addicted non-small cell lung cancer adaptive resistance to targeted therapies," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Ziheng Chen & I-Lin Ho & Melinda Soeung & Er-Yen Yen & Jintan Liu & Liang Yan & Johnathon L. Rose & Sanjana Srinivasan & Shan Jiang & Q. Edward Chang & Ningping Feng & Jason P. Gay & Qi Wang & Jing Wa, 2023. "Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Yuanli Zhen & Kai Liu & Lei Shi & Simran Shah & Qin Xu & Haley Ellis & Eranga R. Balasooriya & Johannes Kreuzer & Robert Morris & Albert S. Baldwin & Dejan Juric & Wilhelm Haas & Nabeel Bardeesy, 2024. "FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    5. Amr Khalifa & Ana Guijarro & Silvia Ravera & Nadia Bertola & Maria Pia Adorni & Bianca Papotti & Lizzia Raffaghello & Roberto Benelli & Pamela Becherini & Asmaa Namatalla & Daniela Verzola & Daniele R, 2023. "Cyclic fasting bolsters cholesterol biosynthesis inhibitors’ anticancer activity," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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