IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v514y2014i7521d10.1038_nature13585.html
   My bibliography  Save this article

Inappropriate p53 activation during development induces features of CHARGE syndrome

Author

Listed:
  • Jeanine L. Van Nostrand

    (Stanford University School of Medicine)

  • Colleen A. Brady

    (Stanford University School of Medicine
    Present addresses: Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA (C.A.B.); Department of Medicine, University of Central Florida, Orlando, Florida 32827, USA (M.M.K.); Department of Emergency Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA (T.M.J.).)

  • Heiyoun Jung

    (Stanford University School of Medicine)

  • Daniel R. Fuentes

    (Stanford University School of Medicine)

  • Margaret M. Kozak

    (Stanford University School of Medicine
    Present addresses: Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA (C.A.B.); Department of Medicine, University of Central Florida, Orlando, Florida 32827, USA (M.M.K.); Department of Emergency Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA (T.M.J.).)

  • Thomas M. Johnson

    (Stanford University School of Medicine
    Present addresses: Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA (C.A.B.); Department of Medicine, University of Central Florida, Orlando, Florida 32827, USA (M.M.K.); Department of Emergency Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA (T.M.J.).)

  • Chieh-Yu Lin

    (Stanford University School of Medicine)

  • Chien-Jung Lin

    (Stanford University School of Medicine)

  • Donald L. Swiderski

    (The University of Michigan Medical School)

  • Hannes Vogel

    (Stanford University School of Medicine)

  • Jonathan A. Bernstein

    (Stanford University School of Medicine)

  • Tania Attié-Bitach

    (Hôpital Necker-Enfants Malades, APHP
    Unite INSERM U1163, Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine)

  • Ching-Pin Chang

    (Krannert Institute of Cardiology, Indiana University School of Medicine)

  • Joanna Wysocka

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Donna M. Martin

    (The University of Michigan Medical School
    The University of Michigan Medical School)

  • Laura D. Attardi

    (Stanford University School of Medicine
    Stanford University School of Medicine)

Abstract

Inappropriate activation of the tumour-suppressor protein p53 during development can promote phenotypes similar to those of CHARGE syndrome, suggesting that p53 activation not only has a beneficial function in suppressing cancer but also a deleterious function in promoting developmental syndromes.

Suggested Citation

  • Jeanine L. Van Nostrand & Colleen A. Brady & Heiyoun Jung & Daniel R. Fuentes & Margaret M. Kozak & Thomas M. Johnson & Chieh-Yu Lin & Chien-Jung Lin & Donald L. Swiderski & Hannes Vogel & Jonathan A., 2014. "Inappropriate p53 activation during development induces features of CHARGE syndrome," Nature, Nature, vol. 514(7521), pages 228-232, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7521:d:10.1038_nature13585
    DOI: 10.1038/nature13585
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13585
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13585?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Caojie Liu & Qiuchan Xiong & Qiwen Li & Weimin Lin & Shuang Jiang & Danting Zhang & Yuan Wang & Xiaobo Duan & Ping Gong & Ning Kang, 2022. "CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Jing Nie & Yoshitomo Ueda & Alexander J. Solivais & Eri Hashino, 2022. "CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:514:y:2014:i:7521:d:10.1038_nature13585. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.