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Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

Author

Listed:
  • Xiaoting Wang

    (Genentech)

  • Naruhisa Ota

    (Genentech)

  • Paolo Manzanillo

    (Genentech)

  • Lance Kates

    (Genentech)

  • Jose Zavala-Solorio

    (Genentech)

  • Celine Eidenschenk

    (Genentech)

  • Juan Zhang

    (Genentech)

  • Justin Lesch

    (Genentech)

  • Wyne P. Lee

    (Genentech)

  • Jed Ross

    (Genentech)

  • Lauri Diehl

    (Genentech)

  • Nicholas van Bruggen

    (Genentech)

  • Ganesh Kolumam

    (Genentech)

  • Wenjun Ouyang

    (Genentech)

Abstract

In pre-clinical mouse models, the interleukin-22 pathway is identified as a novel target for therapeutic intervention in metabolic diseases.

Suggested Citation

  • Xiaoting Wang & Naruhisa Ota & Paolo Manzanillo & Lance Kates & Jose Zavala-Solorio & Celine Eidenschenk & Juan Zhang & Justin Lesch & Wyne P. Lee & Jed Ross & Lauri Diehl & Nicholas van Bruggen & Gan, 2014. "Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes," Nature, Nature, vol. 514(7521), pages 237-241, October.
    • Handle: RePEc:nat:nature:v:514:y:2014:i:7521:d:10.1038_nature13564
    DOI: 10.1038/nature13564
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    Cited by:

    1. Zahraa Al Bander & Marloes Dekker Nitert & Aya Mousa & Negar Naderpoor, 2020. "The Gut Microbiota and Inflammation: An Overview," IJERPH, MDPI, vol. 17(20), pages 1-21, October.
    2. Haressh Sajiir & Kuan Yau Wong & Alexandra Müller & Sahar Keshvari & Lucy Burr & Elena Aiello & Teresa Mezza & Andrea Giaccari & Guido Sebastiani & Francesco Dotta & Grant A. Ramm & Graeme A. Macdonal, 2024. "Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Natalia Di Tommaso & Antonio Gasbarrini & Francesca Romana Ponziani, 2021. "Intestinal Barrier in Human Health and Disease," IJERPH, MDPI, vol. 18(23), pages 1-23, December.
    4. Stephen J. Gaudino & Ankita Singh & Huakang Huang & Jyothi Padiadpu & Makheni Jean-Pierre & Cody Kempen & Tej Bahadur & Kiyoshi Shiomitsu & Richard Blumberg & Kenneth R. Shroyer & Semir Beyaz & Natali, 2024. "Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. Haressh Sajiir & Sahar Keshvari & Kuan Yau Wong & Danielle J. Borg & Frederik J. Steyn & Christian Fercher & Karin Taylor & Breten Taylor & Ross T. Barnard & Alexandra Müller & Md Moniruzzaman & Grego, 2024. "Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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