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Chemistry: Chemical con artists foil drug discovery

Author

Listed:
  • Jonathan Baell

    (Jonathan Baell is professor of medicinal chemistry at Monash University in Melbourne, Australia.)

  • Michael A. Walters

    (Michael A. Walters is research associate professor of medicinal chemistry at the University of Minnesota in Minneapolis, USA.)

Abstract

Naivety about promiscuous, assay-duping molecules is polluting the literature and wasting resources, warn Jonathan Baell and Michael A. Walters.

Suggested Citation

  • Jonathan Baell & Michael A. Walters, 2014. "Chemistry: Chemical con artists foil drug discovery," Nature, Nature, vol. 513(7519), pages 481-483, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7519:d:10.1038_513481a
    DOI: 10.1038/513481a
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    Cited by:

    1. Johannes Dopfer & James D. Vasta & Susanne Müller & Stefan Knapp & Matthew B. Robers & Martin P. Schwalm, 2024. "tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis," Nature Communications, Nature, vol. 15(1), pages 1-5, December.
    2. Emmanouil Zacharioudakis & Bogos Agianian & Vasantha Kumar MV & Nikolaos Biris & Thomas P. Garner & Inna Rabinovich-Nikitin & Amanda T. Ouchida & Victoria Margulets & Lars Ulrik Nordstrøm & Joel S. Ri, 2022. "Modulating mitofusins to control mitochondrial function and signaling," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Jan Aaseth & Aleksandra Buha & David R. Wallace & Geir Bjørklund, 2020. "Xenobiotics, Trace Metals and Genetics in the Pathogenesis of Tauopathies," IJERPH, MDPI, vol. 17(4), pages 1-11, February.
    4. Jayden Sterling & Jennifer R. Baker & Adam McCluskey & Lenka Munoz, 2023. "Systematic literature review reveals suboptimal use of chemical probes in cell-based biomedical research," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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