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Bidirectional switch of the valence associated with a hippocampal contextual memory engram

Author

Listed:
  • Roger L. Redondo

    (RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

  • Joshua Kim

    (RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Autumn L. Arons

    (RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

  • Steve Ramirez

    (RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Xu Liu

    (RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

  • Susumu Tonegawa

    (RIKEN–MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

Abstract

An optogenetic approach in mice was used to investigate the neural mechanisms underlying memory valence association; dentate gyrus, but not amygdala, memory engram cells exhibit plasticity in valence associations, suggesting that emotional memory associations can be changed at the circuit level.

Suggested Citation

  • Roger L. Redondo & Joshua Kim & Autumn L. Arons & Steve Ramirez & Xu Liu & Susumu Tonegawa, 2014. "Bidirectional switch of the valence associated with a hippocampal contextual memory engram," Nature, Nature, vol. 513(7518), pages 426-430, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7518:d:10.1038_nature13725
    DOI: 10.1038/nature13725
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    Cited by:

    1. Rodrigo Ordoñez Sierra & Lizeth Katherine Pedraza & Lívia Barcsai & Andrea Pejin & Qun Li & Gábor Kozák & Yuichi Takeuchi & Anett J. Nagy & Magor L. Lőrincz & Orrin Devinsky & György Buzsáki & Antal B, 2023. "Closed-loop brain stimulation augments fear extinction in male rats," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Alexandros A. Lavdas & Nikos A. Salingaros, 2022. "Architectural Beauty: Developing a Measurable and Objective Scale," Challenges, MDPI, vol. 13(2), pages 1-32, October.
    3. Dheeraj S. Roy & Young-Gyun Park & Minyoung E. Kim & Ying Zhang & Sachie K. Ogawa & Nicholas DiNapoli & Xinyi Gu & Jae H. Cho & Heejin Choi & Lee Kamentsky & Jared Martin & Olivia Mosto & Tomomi Aida , 2022. "Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Yann Vanrobaeys & Utsav Mukherjee & Lucy Langmack & Stacy E. Beyer & Ethan Bahl & Li-Chun Lin & Jacob J. Michaelson & Ted Abel & Snehajyoti Chatterjee, 2023. "Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Stephanie L. Grella & Amanda H. Fortin & Evan Ruesch & John H. Bladon & Leanna F. Reynolds & Abby Gross & Monika Shpokayte & Christine Cincotta & Yosif Zaki & Steve Ramirez, 2022. "Reactivating hippocampal-mediated memories during reconsolidation to disrupt fear," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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