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Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria

Author

Listed:
  • Qingfeng Zhang

    (Research Center for Translational Medicine, Shanghai East Hospital and Institute of Infectious Diseases and Vaccine Development, Tongji University School of Medicine
    Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
    CNRS, URA 2581, F-75724 Paris, France)

  • T. Nicolai Siegel

    (Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
    CNRS, URA 2581, F-75724 Paris, France
    Present address: Research Center for Infectious Diseases, University of Würzburg, 97080 Würzburg, Germany.)

  • Rafael M. Martins

    (Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
    CNRS, URA 2581, F-75724 Paris, France)

  • Fei Wang

    (Research Center for Translational Medicine, Shanghai East Hospital and Institute of Infectious Diseases and Vaccine Development, Tongji University School of Medicine)

  • Jun Cao

    (Jiangsu Institute of Parasitic Diseases, Key Laboratory of Parasitic Disease Control and Prevention (Ministry of Health), and Jiangsu Provincial Key Laboratory of Parasite Molecular Biology)

  • Qi Gao

    (Jiangsu Institute of Parasitic Diseases, Key Laboratory of Parasitic Disease Control and Prevention (Ministry of Health), and Jiangsu Provincial Key Laboratory of Parasite Molecular Biology)

  • Xiu Cheng

    (Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences)

  • Lubin Jiang

    (Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences)

  • Chung-Chau Hon

    (Cell Biology of Parasitism Unit, Institut Pasteur, and INSERM U786, F-75724 Paris, France)

  • Christine Scheidig-Benatar

    (Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
    CNRS, URA 2581, F-75724 Paris, France)

  • Hiroshi Sakamoto

    (Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
    CNRS, URA 2581, F-75724 Paris, France)

  • Louise Turner

    (Centre for Medical Parasitology, Immunology & Microbiology, Faculty of Health and Medical Sciences, Copenhagen University Hospital (Rigshospitalet))

  • Anja T. R. Jensen

    (Centre for Medical Parasitology, Immunology & Microbiology, Faculty of Health and Medical Sciences, Copenhagen University Hospital (Rigshospitalet))

  • Aurelie Claes

    (Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
    CNRS, URA 2581, F-75724 Paris, France)

  • Julien Guizetti

    (Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
    CNRS, URA 2581, F-75724 Paris, France)

  • Nicholas A. Malmquist

    (Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
    CNRS, URA 2581, F-75724 Paris, France)

  • Artur Scherf

    (Unité de Biologie des Interactions Hôte–Parasite, Institut Pasteur, F-75724 Paris, France
    CNRS, URA 2581, F-75724 Paris, France)

Abstract

A novel type of post-transcriptional regulation controls the expression of virulence genes in blood-stage malaria parasites.

Suggested Citation

  • Qingfeng Zhang & T. Nicolai Siegel & Rafael M. Martins & Fei Wang & Jun Cao & Qi Gao & Xiu Cheng & Lubin Jiang & Chung-Chau Hon & Christine Scheidig-Benatar & Hiroshi Sakamoto & Louise Turner & Anja T, 2014. "Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria," Nature, Nature, vol. 513(7518), pages 431-435, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7518:d:10.1038_nature13468
    DOI: 10.1038/nature13468
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    Cited by:

    1. Mwikali Kioko & Alena Pance & Shaban Mwangi & David Goulding & Alison Kemp & Martin Rono & Lynette Isabella Ochola-Oyier & Pete C. Bull & Philip Bejon & Julian C. Rayner & Abdirahman I. Abdi, 2023. "Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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