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RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

Author

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  • Marius Dannappel

    (Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany)

  • Katerina Vlantis

    (Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany)

  • Snehlata Kumari

    (Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany)

  • Apostolos Polykratis

    (Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany)

  • Chun Kim

    (Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany)

  • Laurens Wachsmuth

    (Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany)

  • Christina Eftychi

    (Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany)

  • Juan Lin

    (Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany)

  • Teresa Corona

    (Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany)

  • Nicole Hermance

    (University of Massachusetts Medical School)

  • Matija Zelic

    (University of Massachusetts Medical School)

  • Petra Kirsch

    (Tierforschungszentrum, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany)

  • Marijana Basic

    (Institute for Laboratory Animal Science, Hannover Medical School, D-30625 Hannover, Germany)

  • Andre Bleich

    (Institute for Laboratory Animal Science, Hannover Medical School, D-30625 Hannover, Germany)

  • Michelle Kelliher

    (University of Massachusetts Medical School)

  • Manolis Pasparakis

    (Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany)

Abstract

RIPK1 is shown to have a crucial role—independent of its known kinase function—in suppressing epithelial cell apoptosis and necroptosis in mice, thereby regulating homeostasis and preventing inflammation in barrier tissues.

Suggested Citation

  • Marius Dannappel & Katerina Vlantis & Snehlata Kumari & Apostolos Polykratis & Chun Kim & Laurens Wachsmuth & Christina Eftychi & Juan Lin & Teresa Corona & Nicole Hermance & Matija Zelic & Petra Kirs, 2014. "RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis," Nature, Nature, vol. 513(7516), pages 90-94, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7516:d:10.1038_nature13608
    DOI: 10.1038/nature13608
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    Cited by:

    1. Hannah Schünke & Ulrike Göbel & Ivan Dikic & Manolis Pasparakis, 2021. "OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Yanxiang Meng & Sarah E. Garnish & Katherine A. Davies & Katrina A. Black & Andrew P. Leis & Christopher R. Horne & Joanne M. Hildebrand & Hanadi Hoblos & Cheree Fitzgibbon & Samuel N. Young & Toby Di, 2023. "Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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