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Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells

Author

Listed:
  • Zohar Shipony

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Zohar Mukamel

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Netta Mendelson Cohen

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Gilad Landan

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Elad Chomsky

    (Weizmann Institute of Science, Rehovot 76100, Israel
    Weizmann Institute of Science, Rehovot 76100, Israel)

  • Shlomit Reich Zeliger

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Yael Chagit Fried

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Elena Ainbinder

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Nir Friedman

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Amos Tanay

    (Weizmann Institute of Science, Rehovot 76100, Israel)

Abstract

Using a new method to estimate DNA methylation turnover rate, embryonic stem cells are shown to lack clonal transmission of methylation but still maintain a stable epigenetic state, whereas somatic cells transmit methylation clonally but lose epigenetic state coherence owing to the persistence of accumulated methylation errors.

Suggested Citation

  • Zohar Shipony & Zohar Mukamel & Netta Mendelson Cohen & Gilad Landan & Elad Chomsky & Shlomit Reich Zeliger & Yael Chagit Fried & Elena Ainbinder & Nir Friedman & Amos Tanay, 2014. "Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells," Nature, Nature, vol. 513(7516), pages 115-119, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7516:d:10.1038_nature13458
    DOI: 10.1038/nature13458
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    Cited by:

    1. Uri Weissbein & Omer Plotnik & Dan Vershkov & Nissim Benvenisty, 2017. "Culture-induced recurrent epigenetic aberrations in human pluripotent stem cells," PLOS Genetics, Public Library of Science, vol. 13(8), pages 1-16, August.
    2. Allegra Angeloni & Skye Fissette & Deniz Kaya & Jillian M. Hammond & Hasindu Gamaarachchi & Ira W. Deveson & Robert J. Klose & Weiming Li & Xiaotian Zhang & Ozren Bogdanovic, 2024. "Extensive DNA methylome rearrangement during early lamprey embryogenesis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Amir D. Hay & Noah J. Kessler & Daniel Gebert & Nozomi Takahashi & Hugo Tavares & Felipe K. Teixeira & Anne C. Ferguson-Smith, 2023. "Epigenetic inheritance is unfaithful at intermediately methylated CpG sites," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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