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Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1

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  • Phong Dang Nguyen

    (Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia)

  • Georgina Elizabeth Hollway

    (The Kinghorn Cancer Centre & Cancer Research Program, Garvan Institute of Medical Research, Victoria Street, Darlinghurst, New South Wales 2010, Australia
    St Vincent's Clinical School, Faculty of Medicine, University of New South Wales)

  • Carmen Sonntag

    (Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia)

  • Lee Barry Miles

    (Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia)

  • Thomas Edward Hall

    (Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia)

  • Silke Berger

    (Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia)

  • Kristine Joy Fernandez

    (The Kinghorn Cancer Centre & Cancer Research Program, Garvan Institute of Medical Research, Victoria Street, Darlinghurst, New South Wales 2010, Australia)

  • David Baruch Gurevich

    (Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia)

  • Nicholas James Cole

    (University of Sydney Medical School Anderson Stuart Building University of Sydney
    MND Research Program, Australian School of Advanced Medicine, Macquarie University)

  • Sara Alaei

    (Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    Monash University, Wellington Road, Clayton Victoria 3800, Australia)

  • Mirana Ramialison

    (Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia)

  • Robert Lyndsay Sutherland

    (The Kinghorn Cancer Centre & Cancer Research Program, Garvan Institute of Medical Research, Victoria Street, Darlinghurst, New South Wales 2010, Australia
    St Vincent's Clinical School, Faculty of Medicine, University of New South Wales)

  • Jose Maria Polo

    (Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    Monash University, Wellington Road, Clayton Victoria 3800, Australia)

  • Graham John Lieschke

    (Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia)

  • Peter David Currie

    (Australian Regenerative Medicine Institute, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    EMBL Australia, Level 1, Building 75, Monash University, Wellington Road, Clayton, Victoria 3800, Australia)

Abstract

A new somite compartment, called the endotome, that contributes to the formation of the embryonic dorsal aorta by providing endothelial progenitors is identified here; endotome-derived endothelial progenitors, whose formation is regulated by the activity of the meox1 gene, induce haematopoietic stem cell formation upon colonization of the nascent dorsal aorta.

Suggested Citation

  • Phong Dang Nguyen & Georgina Elizabeth Hollway & Carmen Sonntag & Lee Barry Miles & Thomas Edward Hall & Silke Berger & Kristine Joy Fernandez & David Baruch Gurevich & Nicholas James Cole & Sara Alae, 2014. "Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1," Nature, Nature, vol. 512(7514), pages 314-318, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7514:d:10.1038_nature13678
    DOI: 10.1038/nature13678
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    Cited by:

    1. Emi Murayama & Catherine Vivier & Anne Schmidt & Philippe Herbomel, 2023. "Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Brandon Hadland & Barbara Varnum-Finney & Stacey Dozono & Tessa Dignum & Cynthia Nourigat-McKay & Adam M. Heck & Takashi Ishida & Dana L. Jackson & Tomer Itkin & Jason M. Butler & Shahin Rafii & Cole , 2022. "Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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