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Visualization of arrestin recruitment by a G-protein-coupled receptor

Author

Listed:
  • Arun K. Shukla

    (Duke University Medical Center
    Present address: Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.)

  • Gerwin H. Westfield

    (University of Michigan Medical School)

  • Kunhong Xiao

    (Duke University Medical Center)

  • Rosana I. Reis

    (Duke University Medical Center)

  • Li-Yin Huang

    (Duke University Medical Center)

  • Prachi Tripathi-Shukla

    (Duke University Medical Center)

  • Jiang Qian

    (Duke University Medical Center)

  • Sheng Li

    (University of California at San Diego)

  • Adi Blanc

    (Duke University Medical Center)

  • Austin N. Oleskie

    (University of Michigan Medical School)

  • Anne M. Dosey

    (University of Michigan Medical School)

  • Min Su

    (University of Michigan Medical School)

  • Cui-Rong Liang

    (School of Pharmaceutical & Life Sciences, Changzhou University, Changzhou, Jiangsu 213164, China)

  • Ling-Ling Gu

    (School of Pharmaceutical & Life Sciences, Changzhou University, Changzhou, Jiangsu 213164, China)

  • Jin-Ming Shan

    (School of Pharmaceutical & Life Sciences, Changzhou University, Changzhou, Jiangsu 213164, China)

  • Xin Chen

    (School of Pharmaceutical & Life Sciences, Changzhou University, Changzhou, Jiangsu 213164, China)

  • Rachel Hanna

    (Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Minjung Choi

    (Duke University Medical Center)

  • Xiao Jie Yao

    (Duke University Medical Center)

  • Bjoern U. Klink

    (Duke University Medical Center)

  • Alem W. Kahsai

    (Duke University Medical Center)

  • Sachdev S. Sidhu

    (Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Shohei Koide

    (University of Chicago)

  • Pawel A. Penczek

    (The University of Texas Medical School at Houston)

  • Anthony A. Kossiakoff

    (University of Chicago)

  • Virgil L. Woods Jr

    (University of California at San Diego)

  • Brian K. Kobilka

    (Stanford University School of Medicine, 279 Campus Drive)

  • Georgios Skiniotis

    (University of Michigan Medical School)

  • Robert J. Lefkowitz

    (Duke University Medical Center
    Duke University Medical Center
    Howard Hughes Medical Institute, Duke University Medical Center)

Abstract

Single-particle electron microscopy and hydrogen–deuterium exchange mass spectrometry are used to characterize the structure and dynamics of a G-protein-coupled receptor–arrestin complex.

Suggested Citation

  • Arun K. Shukla & Gerwin H. Westfield & Kunhong Xiao & Rosana I. Reis & Li-Yin Huang & Prachi Tripathi-Shukla & Jiang Qian & Sheng Li & Adi Blanc & Austin N. Oleskie & Anne M. Dosey & Min Su & Cui-Rong, 2014. "Visualization of arrestin recruitment by a G-protein-coupled receptor," Nature, Nature, vol. 512(7513), pages 218-222, August.
    • Handle: RePEc:nat:nature:v:512:y:2014:i:7513:d:10.1038_nature13430
    DOI: 10.1038/nature13430
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    Citations

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    Cited by:

    1. Alexa Strauss & Alberto J. Gonzalez-Hernandez & Joon Lee & Nohely Abreu & Purushotham Selvakumar & Leslie Salas-Estrada & Melanie Kristt & Anisul Arefin & Kevin Huynh & Dagan C. Marx & Kristen Gillila, 2024. "Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Yutaro Shiraishi & Yutaka Kofuku & Takumi Ueda & Shubhi Pandey & Hemlata Dwivedi-Agnihotri & Arun K. Shukla & Ichio Shimada, 2021. "Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    3. Ruibo Zhai & Zhuoqi Wang & Zhaofei Chai & Xiaogang Niu & Conggang Li & Changwen Jin & Yunfei Hu, 2023. "Distinct activation mechanisms of β-arrestin-1 revealed by 19F NMR spectroscopy," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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