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DNA methylation dynamics of the human preimplantation embryo

Author

Listed:
  • Zachary D. Smith

    (Broad Institute of MIT and Harvard
    Harvard Stem Cell Institute
    Harvard University
    Harvard University)

  • Michelle M. Chan

    (Broad Institute of MIT and Harvard
    Computational and Systems Biology Program, Massachusetts Institute of Technology)

  • Kathryn C. Humm

    (Harvard University
    Beth Israel Deaconess Medical Center
    Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School
    Boston IVF)

  • Rahul Karnik

    (Broad Institute of MIT and Harvard
    Harvard Stem Cell Institute
    Harvard University)

  • Shila Mekhoubad

    (Harvard University
    Harvard University)

  • Aviv Regev

    (Broad Institute of MIT and Harvard
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Kevin Eggan

    (Broad Institute of MIT and Harvard
    Harvard Stem Cell Institute
    Harvard University
    Harvard University)

  • Alexander Meissner

    (Broad Institute of MIT and Harvard
    Harvard Stem Cell Institute
    Harvard University)

Abstract

Genome-scale DNA methylation maps over early human embryogenesis and embryonic stem cell derivation provide insights into shared and unique modes of regulation when compared to the mouse model, including relationships to gene expression, transposable element activity, and maternal-specific methylation.

Suggested Citation

  • Zachary D. Smith & Michelle M. Chan & Kathryn C. Humm & Rahul Karnik & Shila Mekhoubad & Aviv Regev & Kevin Eggan & Alexander Meissner, 2014. "DNA methylation dynamics of the human preimplantation embryo," Nature, Nature, vol. 511(7511), pages 611-615, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7511:d:10.1038_nature13581
    DOI: 10.1038/nature13581
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    Cited by:

    1. Liu Yang & San-Jian Yu & Qi Hong & Yu Yang & Zhi-Ming Shao, 2015. "Reduced Expression of TET1, TET2, TET3 and TDG mRNAs Are Associated with Poor Prognosis of Patients with Early Breast Cancer," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-10, July.
    2. Denis Torre & Nancy J. Francoeur & Yael Kalma & Ilana Gross Carmel & Betsaida S. Melo & Gintaras Deikus & Kimaada Allette & Ron Flohr & Maya Fridrikh & Konstantinos Vlachos & Kent Madrid & Hardik Shah, 2023. "Isoform-resolved transcriptome of the human preimplantation embryo," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    3. Jiajun Tan & Yingfeng Li & Xiang Li & Xiaoxiao Zhu & Liping Liu & Hua Huang & Jiahua Wei & Hailing Wang & Yong Tian & Zhigao Wang & Zhuqiang Zhang & Bing Zhu, 2024. "Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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