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The DNA methylation landscape of human early embryos

Author

Listed:
  • Hongshan Guo

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University)

  • Ping Zhu

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Peking-Tsinghua Center for Life Sciences, Peking University)

  • Liying Yan

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Key Laboratory of Assisted Reproduction, Ministry of Education)

  • Rong Li

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Key Laboratory of Assisted Reproduction, Ministry of Education)

  • Boqiang Hu

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University)

  • Ying Lian

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Key Laboratory of Assisted Reproduction, Ministry of Education)

  • Jie Yan

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Key Laboratory of Assisted Reproduction, Ministry of Education)

  • Xiulian Ren

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Key Laboratory of Assisted Reproduction, Ministry of Education)

  • Shengli Lin

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Key Laboratory of Assisted Reproduction, Ministry of Education)

  • Junsheng Li

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Key Laboratory of Assisted Reproduction, Ministry of Education)

  • Xiaohu Jin

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Key Laboratory of Assisted Reproduction, Ministry of Education)

  • Xiaodan Shi

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Key Laboratory of Assisted Reproduction, Ministry of Education)

  • Ping Liu

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Key Laboratory of Assisted Reproduction, Ministry of Education)

  • Xiaoye Wang

    (Peking University Third Hospital)

  • Wei Wang

    (Peking University Third Hospital)

  • Yuan Wei

    (Peking University Third Hospital)

  • Xianlong Li

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University)

  • Fan Guo

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University)

  • Xinglong Wu

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University)

  • Xiaoying Fan

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University)

  • Jun Yong

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Harvard University)

  • Lu Wen

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University)

  • Sunney X. Xie

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Harvard University)

  • Fuchou Tang

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 100871, China)

  • Jie Qiao

    (Biodynamic Optical Imaging Center & Center for Reproductive Medicine, College of Life Sciences, Third Hospital, Peking University
    Key Laboratory of Assisted Reproduction, Ministry of Education)

Abstract

Base-resolution maps of DNA methylation in human gametes and early embryos offer novel insights into human methylation dynamics and the functional relationship between DNA methylation and gene expression.

Suggested Citation

  • Hongshan Guo & Ping Zhu & Liying Yan & Rong Li & Boqiang Hu & Ying Lian & Jie Yan & Xiulian Ren & Shengli Lin & Junsheng Li & Xiaohu Jin & Xiaodan Shi & Ping Liu & Xiaoye Wang & Wei Wang & Yuan Wei & , 2014. "The DNA methylation landscape of human early embryos," Nature, Nature, vol. 511(7511), pages 606-610, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7511:d:10.1038_nature13544
    DOI: 10.1038/nature13544
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    Citations

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    Cited by:

    1. Ariane Lismer & Sarah Kimmins, 2023. "Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Jiajun Tan & Yingfeng Li & Xiang Li & Xiaoxiao Zhu & Liping Liu & Hua Huang & Jiahua Wei & Hailing Wang & Yong Tian & Zhigao Wang & Zhuqiang Zhang & Bing Zhu, 2024. "Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Rebecca Jean Ryznar & Lacie Phibbs & Lon J. Van Winkle, 2021. "Epigenetic Modifications at the Center of the Barker Hypothesis and Their Transgenerational Implications," IJERPH, MDPI, vol. 18(23), pages 1-12, December.
    4. Henry J. Leese & Paul J. McKeegan & Roger G. Sturmey, 2021. "Amino Acids and the Early Mammalian Embryo: Origin, Fate, Function and Life-Long Legacy," IJERPH, MDPI, vol. 18(18), pages 1-19, September.
    5. Denis Torre & Nancy J. Francoeur & Yael Kalma & Ilana Gross Carmel & Betsaida S. Melo & Gintaras Deikus & Kimaada Allette & Ron Flohr & Maya Fridrikh & Konstantinos Vlachos & Kent Madrid & Hardik Shah, 2023. "Isoform-resolved transcriptome of the human preimplantation embryo," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    6. Wenwen Li & Ann Van Soom & Luc Peelman, 2017. "Repeats as global DNA methylation marker in bovine preimplantation embryos," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 62(2), pages 43-50.

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