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Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Author

Listed:
  • Anila K. Madiraju

    (Yale University School of Medicine
    Yale University School of Medicine
    Howard Hughes Medical Institute, Yale University School of Medicine)

  • Derek M. Erion

    (Yale University School of Medicine
    Yale University School of Medicine
    Howard Hughes Medical Institute, Yale University School of Medicine)

  • Yasmeen Rahimi

    (Yale University School of Medicine)

  • Xian-Man Zhang

    (Yale University School of Medicine)

  • Demetrios T. Braddock

    (Yale University School of Medicine)

  • Ronald A. Albright

    (Yale University School of Medicine)

  • Brett J. Prigaro

    (Colorado State University)

  • John L. Wood

    (Cancer Prevention Research Institute of Texas Scholar, Baylor University)

  • Sanjay Bhanot

    (Isis Pharmaceuticals, 2855 Gazelle Court)

  • Michael J. MacDonald

    (University of Wisconsin School of Medicine and Public Health, Madison)

  • Michael J. Jurczak

    (Yale University School of Medicine)

  • Joao-Paulo Camporez

    (Yale University School of Medicine)

  • Hui-Young Lee

    (Yale University School of Medicine)

  • Gary W. Cline

    (Yale University School of Medicine)

  • Varman T. Samuel

    (Yale University School of Medicine)

  • Richard G. Kibbey

    (Yale University School of Medicine
    Yale University School of Medicine)

  • Gerald I. Shulman

    (Yale University School of Medicine
    Yale University School of Medicine
    Howard Hughes Medical Institute, Yale University School of Medicine
    Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark, DK-2200)

Abstract

Metformin treatment of rats at physiologically relevant doses inhibits the redox shuttle enzyme mitochondrial glycerophosphate dehydrogenase.

Suggested Citation

  • Anila K. Madiraju & Derek M. Erion & Yasmeen Rahimi & Xian-Man Zhang & Demetrios T. Braddock & Ronald A. Albright & Brett J. Prigaro & John L. Wood & Sanjay Bhanot & Michael J. MacDonald & Michael J. , 2014. "Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase," Nature, Nature, vol. 510(7506), pages 542-546, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7506:d:10.1038_nature13270
    DOI: 10.1038/nature13270
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    Cited by:

    1. Eryun Zhang & Lihua Jin & Yangmeng Wang & Jui Tu & Ruirong Zheng & Lili Ding & Zhipeng Fang & Mingjie Fan & Ismail Al-Abdullah & Rama Natarajan & Ke Ma & Zhengtao Wang & Arthur D. Riggs & Sarah C. Shu, 2022. "Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. M. Sinn & L. Riede & J. R. Fleming & D. Funck & H. Lutz & A. Bachmann & O. Mayans & J. S. Hartig, 2024. "Metformin hydrolase is a recently evolved nickel-dependent heteromeric ureohydrolase," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    3. Alessandra Dall’Agnese & Jesse M. Platt & Ming M. Zheng & Max Friesen & Giuseppe Dall’Agnese & Alyssa M. Blaise & Jessica B. Spinelli & Jonathan E. Henninger & Erin N. Tevonian & Nancy M. Hannett & Ch, 2022. "The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    4. Joyce S. Ramos & Lance C. Dalleck & Caitlin E. Keith & Mackenzie Fennell & Zoe Lee & Claire Drummond & Shelley E. Keating & Robert G. Fassett & Jeff S. Coombes, 2020. "Optimizing the Interaction of Exercise Volume and Metformin to Induce a Clinically Significant Reduction in Metabolic Syndrome Severity: A Randomised Trial," IJERPH, MDPI, vol. 17(10), pages 1-14, May.
    5. Motohiro Sekiya & Kenta Kainoh & Takehito Sugasawa & Ryunosuke Yoshino & Takatsugu Hirokawa & Hiroaki Tokiwa & Shogo Nakano & Satoru Nagatoishi & Kouhei Tsumoto & Yoshinori Takeuchi & Takafumi Miyamot, 2021. "The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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