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Metformin intake associates with better cognitive function in patients with Huntington's disease

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  • David Hervás
  • Victoria Fornés-Ferrer
  • Ana Pilar Gómez-Escribano
  • María Dolores Sequedo
  • Carmen Peiró
  • José María Millán
  • Rafael P Vázquez-Manrique

Abstract

Huntington’s disease (HD) is an inherited, dominant neurodegenerative disorder caused by an abnormal expansion of CAG triplets in the huntingtin gene (htt). Despite extensive efforts to modify the progression of HD thus far only symptomatic treatment is available. Recent work suggests that treating invertebrate and mice HD models with metformin, a well-known AMPK activator which is used worldwide to treat type 2-diabetes, reduces mutant huntingtin from cells and alleviates many of the phenotypes associated to HD. Herein we report statistical analyses of a sample population of participants in the Enroll-HD database, a world-wide observational study on HD, to assess the effect of metformin intake in HD patients respect to cognitive status using linear models. This cross-sectional study shows for the first time that the use of metformin associates with better cognitive function in HD patients.

Suggested Citation

  • David Hervás & Victoria Fornés-Ferrer & Ana Pilar Gómez-Escribano & María Dolores Sequedo & Carmen Peiró & José María Millán & Rafael P Vázquez-Manrique, 2017. "Metformin intake associates with better cognitive function in patients with Huntington's disease," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0179283
    DOI: 10.1371/journal.pone.0179283
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