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Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer

Author

Listed:
  • Curtis M. Schauder

    (Yale School of Medicine)

  • Xudong Wu

    (Yale School of Medicine)

  • Yasunori Saheki

    (Yale School of Medicine
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale School of Medicine, New Haven, Connecticut 06510, USA
    and Howard Hughes Medical Institute, Yale School of Medicine)

  • Pradeep Narayanaswamy

    (National University of Singapore, 117543 Singapore)

  • Federico Torta

    (Yong Loo Lin School of Medicine, National University of Singapore, 117599 Singapore)

  • Markus R. Wenk

    (Yong Loo Lin School of Medicine, National University of Singapore, 117599 Singapore)

  • Pietro De Camilli

    (Yale School of Medicine
    Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale School of Medicine, New Haven, Connecticut 06510, USA
    and Howard Hughes Medical Institute, Yale School of Medicine
    Howard Hughes Medical Institute, Yale School of Medicine)

  • Karin M. Reinisch

    (Yale School of Medicine)

Abstract

Several proteins localized at membrane contact sites contain an SMP domain, which has been proposed to act as a lipid-binding module; here, the crystal structure of a fragment of the extended synaptotagmin 2 protein, including its SMP, is presented, and indicates that this protein may have a direct role in lipid transport.

Suggested Citation

  • Curtis M. Schauder & Xudong Wu & Yasunori Saheki & Pradeep Narayanaswamy & Federico Torta & Markus R. Wenk & Pietro De Camilli & Karin M. Reinisch, 2014. "Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer," Nature, Nature, vol. 510(7506), pages 552-555, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7506:d:10.1038_nature13269
    DOI: 10.1038/nature13269
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    Cited by:

    1. Yunyun Wang & Zhenni Li & Xinyu Wang & Ziyuan Zhao & Li Jiao & Ruming Liu & Keying Wang & Rui Ma & Yang Yang & Guo Chen & Yong Wang & Xin Bian, 2023. "Insights into membrane association of the SMP domain of extended synaptotagmin," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Darshini Jeyasimman & Bilge Ercan & Dennis Dharmawan & Tomoki Naito & Jingbo Sun & Yasunori Saheki, 2021. "PDZD-8 and TEX-2 regulate endosomal PI(4,5)P2 homeostasis via lipid transport to promote embryogenesis in C. elegans," Nature Communications, Nature, vol. 12(1), pages 1-21, December.

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