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mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

Author

Listed:
  • Joseph T. Rodgers

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Katherine Y. King

    (Baylor College of Medicine)

  • Jamie O. Brett

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Melinda J. Cromie

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Gregory W. Charville

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Katie K. Maguire

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Christopher Brunson

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Namrata Mastey

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Ling Liu

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Chang-Ru Tsai

    (Baylor College of Medicine)

  • Margaret A. Goodell

    (Baylor College of Medicine)

  • Thomas A. Rando

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine
    Neurology Service and Rehabilitation Research and Development Center of Excellence, Veterans Affairs Palo Alto Health Care System)

Abstract

A mouse study reveals that the stem cell quiescent state is composed of two distinct phases, G0 and GAlert; stem cells reversibly transition between these two phases in response to systemic environmental stimuli acting through the mTORC1 pathway.

Suggested Citation

  • Joseph T. Rodgers & Katherine Y. King & Jamie O. Brett & Melinda J. Cromie & Gregory W. Charville & Katie K. Maguire & Christopher Brunson & Namrata Mastey & Ling Liu & Chang-Ru Tsai & Margaret A. Goo, 2014. "mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert," Nature, Nature, vol. 510(7505), pages 393-396, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7505:d:10.1038_nature13255
    DOI: 10.1038/nature13255
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    Cited by:

    1. Suyang Zhang & Feng Yang & Yile Huang & Liangqiang He & Yuying Li & Yi Ching Esther Wan & Yingzhe Ding & Kui Ming Chan & Ting Xie & Hao Sun & Huating Wang, 2023. "ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Le Tran Phuc Khoa & Wentao Yang & Mengrou Shan & Li Zhang & Fengbiao Mao & Bo Zhou & Qiang Li & Rebecca Malcore & Clair Harris & Lili Zhao & Rajesh C. Rao & Shigeki Iwase & Sundeep Kalantry & Stephani, 2024. "Quiescence enables unrestricted cell fate in naive embryonic stem cells," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Jacob C Kimmel & Amy Y Chang & Andrew S Brack & Wallace F Marshall, 2018. "Inferring cell state by quantitative motility analysis reveals a dynamic state system and broken detailed balance," PLOS Computational Biology, Public Library of Science, vol. 14(1), pages 1-29, January.
    4. Hue M. La & Jinyue Liao & Julien M. D. Legrand & Fernando J. Rossello & Ai-Leen Chan & Vijesh Vaghjiani & Jason E. Cain & Antonella Papa & Tin Lap Lee & Robin M. Hobbs, 2022. "Distinctive molecular features of regenerative stem cells in the damaged male germline," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. Caroline E. Brun & Marie-Claude Sincennes & Alexander Y. T. Lin & Derek Hall & William Jarassier & Peter Feige & Fabien Le Grand & Michael A. Rudnicki, 2022. "GLI3 regulates muscle stem cell entry into GAlert and self-renewal," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    6. Hongna Zuo & Aiwei Wu & Mingwei Wang & Liquan Hong & Hu Wang, 2024. "tRNA m1A modification regulate HSC maintenance and self-renewal via mTORC1 signaling," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    7. Xiaoyan Wei & Angelos Rigopoulos & Matthias Lienhard & Sophie Pöhle-Kronawitter & Georgios Kotsaris & Julia Franke & Nikolaus Berndt & Joy Orezimena Mejedo & Hao Wu & Stefan Börno & Bernd Timmermann &, 2024. "Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    8. Chee Ho H’ng & Shanika L. Amarasinghe & Boya Zhang & Hojin Chang & Xinli Qu & David R. Powell & Alberto Rosello-Diez, 2024. "Compensatory growth and recovery of cartilage cytoarchitecture after transient cell death in fetal mouse limbs," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    9. Jiayin Peng & Lili Han & Biao Liu & Jiawen Song & Yuang Wang & Kunpeng Wang & Qian Guo & XinYan Liu & Yu Li & Jujin Zhang & Wenqing Wu & Sheng Li & Xin Fu & Cheng-le Zhuang & Weikang Zhang & Shengbao , 2023. "Gli1 marks a sentinel muscle stem cell population for muscle regeneration," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    10. Chao-Hui Chang & Feng Liu & Stefania Militi & Svenja Hester & Reshma Nibhani & Siwei Deng & James Dunford & Aniko Rendek & Zahir Soonawalla & Roman Fischer & Udo Oppermann & Siim Pauklin, 2024. "The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms," Nature Communications, Nature, vol. 15(1), pages 1-29, December.

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