IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v510y2014i7505d10.1038_nature13255.html
   My bibliography  Save this article

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

Author

Listed:
  • Joseph T. Rodgers

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Katherine Y. King

    (Baylor College of Medicine)

  • Jamie O. Brett

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Melinda J. Cromie

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Gregory W. Charville

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Katie K. Maguire

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Christopher Brunson

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Namrata Mastey

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Ling Liu

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine)

  • Chang-Ru Tsai

    (Baylor College of Medicine)

  • Margaret A. Goodell

    (Baylor College of Medicine)

  • Thomas A. Rando

    (Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine
    Stanford University School of Medicine
    Neurology Service and Rehabilitation Research and Development Center of Excellence, Veterans Affairs Palo Alto Health Care System)

Abstract

A mouse study reveals that the stem cell quiescent state is composed of two distinct phases, G0 and GAlert; stem cells reversibly transition between these two phases in response to systemic environmental stimuli acting through the mTORC1 pathway.

Suggested Citation

  • Joseph T. Rodgers & Katherine Y. King & Jamie O. Brett & Melinda J. Cromie & Gregory W. Charville & Katie K. Maguire & Christopher Brunson & Namrata Mastey & Ling Liu & Chang-Ru Tsai & Margaret A. Goo, 2014. "mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert," Nature, Nature, vol. 510(7505), pages 393-396, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7505:d:10.1038_nature13255
    DOI: 10.1038/nature13255
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13255
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13255?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Le Tran Phuc Khoa & Wentao Yang & Mengrou Shan & Li Zhang & Fengbiao Mao & Bo Zhou & Qiang Li & Rebecca Malcore & Clair Harris & Lili Zhao & Rajesh C. Rao & Shigeki Iwase & Sundeep Kalantry & Stephani, 2024. "Quiescence enables unrestricted cell fate in naive embryonic stem cells," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Hue M. La & Jinyue Liao & Julien M. D. Legrand & Fernando J. Rossello & Ai-Leen Chan & Vijesh Vaghjiani & Jason E. Cain & Antonella Papa & Tin Lap Lee & Robin M. Hobbs, 2022. "Distinctive molecular features of regenerative stem cells in the damaged male germline," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Chee Ho H’ng & Shanika L. Amarasinghe & Boya Zhang & Hojin Chang & Xinli Qu & David R. Powell & Alberto Rosello-Diez, 2024. "Compensatory growth and recovery of cartilage cytoarchitecture after transient cell death in fetal mouse limbs," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    4. Chao-Hui Chang & Feng Liu & Stefania Militi & Svenja Hester & Reshma Nibhani & Siwei Deng & James Dunford & Aniko Rendek & Zahir Soonawalla & Roman Fischer & Udo Oppermann & Siim Pauklin, 2024. "The pRb/RBL2-E2F1/4-GCN5 axis regulates cancer stem cell formation and G0 phase entry/exit by paracrine mechanisms," Nature Communications, Nature, vol. 15(1), pages 1-29, December.
    5. Suyang Zhang & Feng Yang & Yile Huang & Liangqiang He & Yuying Li & Yi Ching Esther Wan & Yingzhe Ding & Kui Ming Chan & Ting Xie & Hao Sun & Huating Wang, 2023. "ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    6. Jacob C Kimmel & Amy Y Chang & Andrew S Brack & Wallace F Marshall, 2018. "Inferring cell state by quantitative motility analysis reveals a dynamic state system and broken detailed balance," PLOS Computational Biology, Public Library of Science, vol. 14(1), pages 1-29, January.
    7. Caroline E. Brun & Marie-Claude Sincennes & Alexander Y. T. Lin & Derek Hall & William Jarassier & Peter Feige & Fabien Le Grand & Michael A. Rudnicki, 2022. "GLI3 regulates muscle stem cell entry into GAlert and self-renewal," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    8. Xiaoyan Wei & Angelos Rigopoulos & Matthias Lienhard & Sophie Pöhle-Kronawitter & Georgios Kotsaris & Julia Franke & Nikolaus Berndt & Joy Orezimena Mejedo & Hao Wu & Stefan Börno & Bernd Timmermann &, 2024. "Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    9. Jiayin Peng & Lili Han & Biao Liu & Jiawen Song & Yuang Wang & Kunpeng Wang & Qian Guo & XinYan Liu & Yu Li & Jujin Zhang & Wenqing Wu & Sheng Li & Xin Fu & Cheng-le Zhuang & Weikang Zhang & Shengbao , 2023. "Gli1 marks a sentinel muscle stem cell population for muscle regeneration," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:510:y:2014:i:7505:d:10.1038_nature13255. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.