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Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

Author

Listed:
  • Srdjan Maksimovic

    (Columbia University)

  • Masashi Nakatani

    (Columbia University
    Graduate School of System Design and Management, Keio University, Yokohama 223-8526, Japan)

  • Yoshichika Baba

    (Columbia University)

  • Aislyn M. Nelson

    (Columbia University
    Baylor College of Medicine)

  • Kara L. Marshall

    (Columbia University)

  • Scott A. Wellnitz

    (Baylor College of Medicine)

  • Pervez Firozi

    (Baylor College of Medicine)

  • Seung-Hyun Woo

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute)

  • Sanjeev Ranade

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute)

  • Ardem Patapoutian

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute)

  • Ellen A. Lumpkin

    (Columbia University
    Columbia University
    Program in Neurobiology & Behavior, Columbia University)

Abstract

The cellular basis of touch has long been debated, in particular the relationship between sensory neurons and non-neuronal cells; a mouse study uses optogenetics to identify their distinct and collaborative roles, with skin-derived Merkel cells both transducing touch and actively tuning responses of touch-sensitive neurons.

Suggested Citation

  • Srdjan Maksimovic & Masashi Nakatani & Yoshichika Baba & Aislyn M. Nelson & Kara L. Marshall & Scott A. Wellnitz & Pervez Firozi & Seung-Hyun Woo & Sanjeev Ranade & Ardem Patapoutian & Ellen A. Lumpki, 2014. "Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors," Nature, Nature, vol. 509(7502), pages 617-621, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7502:d:10.1038_nature13250
    DOI: 10.1038/nature13250
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    Citations

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    Cited by:

    1. Elvis K. Boahen & Baohai Pan & Hyukmin Kweon & Joo Sung Kim & Hanbin Choi & Zhengyang Kong & Dong Jun Kim & Jin Zhu & Wu Bin Ying & Kyung Jin Lee & Do Hwan Kim, 2022. "Ultrafast, autonomous self-healable iontronic skin exhibiting piezo-ionic dynamics," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Luis O. Romero & Rebeca Caires & A. Kaitlyn Victor & Juanma Ramirez & Francisco J. Sierra-Valdez & Patrick Walsh & Vincent Truong & Jungsoo Lee & Ugo Mayor & Lawrence T. Reiter & Valeria Vásquez & Jul, 2023. "Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    3. Steven M Barlow & Rebecca Custead, 2019. "Vibrography: Single-Interval Up/Down (SIUD) Adaptive Vibrotactile Threshold Estimation of the Glabrous Hand and Perioral Face in Neurotypical Adults," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 22(4), pages 16837-16847, November.
    4. Julia Ojeda-Alonso & Laura Calvo-Enrique & Ricardo Paricio-Montesinos & Rakesh Kumar & Ming-Dong Zhang & James F. A. Poulet & Patrik Ernfors & Gary R. Lewin, 2024. "Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Clement Verkest & Irina Schaefer & Timo A. Nees & Na Wang & Juri M. Jegelka & Francisco J. Taberner & Stefan G. Lechner, 2022. "Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    6. Yingying Ye & Mohammad Barghouth & Haiqiang Dou & Cheng Luan & Yongzhi Wang & Alexandros Karagiannopoulos & Xiaoping Jiang & Ulrika Krus & Malin Fex & Quan Zhang & Lena Eliasson & Patrik Rorsman & Enm, 2022. "A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    7. Gregory J Gerling & Lingtian Wan & Benjamin U Hoffman & Yuxiang Wang & Ellen A Lumpkin, 2018. "Computation predicts rapidly adapting mechanotransduction currents cannot account for tactile encoding in Merkel cell-neurite complexes," PLOS Computational Biology, Public Library of Science, vol. 14(6), pages 1-21, June.

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