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Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

Author

Listed:
  • Long N. Nguyen

    (Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore)

  • Dongliang Ma

    (Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore)

  • Guanghou Shui

    (National University of Singapore, 8 Medical Drive, Block MD7, 117597 Singapore)

  • Peiyan Wong

    (Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore)

  • Amaury Cazenave-Gassiot

    (National University of Singapore, 8 Medical Drive, Block MD7, 117597 Singapore)

  • Xiaodong Zhang

    (Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore)

  • Markus R. Wenk

    (National University of Singapore, 8 Medical Drive, Block MD7, 117597 Singapore)

  • Eyleen L. K. Goh

    (Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore)

  • David L. Silver

    (Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-NUS Graduate Medical School Singapore, 8 College Road, 169857 Singapore)

Abstract

Mfsd2a is the major transporter of the omega-3 fatty acid docosahexaenoic acid (DHA) into brain, with Mfsd2a-knockout mice showing reduced DHA in brain, neuronal cell loss in hippocampus and cerebellum, behavioural disorders and reduced brain size; DHA is transported in a sodium-dependent manner, in the form of lysophosphatidylcholines (LPCs) carrying long-chain fatty acids.

Suggested Citation

  • Long N. Nguyen & Dongliang Ma & Guanghou Shui & Peiyan Wong & Amaury Cazenave-Gassiot & Xiaodong Zhang & Markus R. Wenk & Eyleen L. K. Goh & David L. Silver, 2014. "Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid," Nature, Nature, vol. 509(7501), pages 503-506, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7501:d:10.1038_nature13241
    DOI: 10.1038/nature13241
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    Cited by:

    1. Tanja Emmerich & Zuchra Zakirova & Nancy Klimas & Kimberly Sullivan & Ashok K Shetty & James E Evans & Ghania Ait-Ghezala & Gary S Laco & Bharathi Hattiangady & Geetha A Shetty & Michael Mullan & Gogc, 2017. "Phospholipid profiling of plasma from GW veterans and rodent models to identify potential biomarkers of Gulf War Illness," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-24, April.
    2. Shana Bergman & Rosemary J. Cater & Ambrose Plante & Filippo Mancia & George Khelashvili, 2023. "Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Elisabeth Lambert & Ahmad Reza Mehdipour & Alexander Schmidt & Gerhard Hummer & Camilo Perez, 2022. "Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Shuhui Wang & Kun Wang & Kangkang Song & Zon Weng Lai & Pengfei Li & Dongying Li & Yajie Sun & Ye Mei & Chen Xu & Maofu Liao, 2024. "Structures of the Mycobacterium tuberculosis efflux pump EfpA reveal the mechanisms of transport and inhibition," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    5. Chi Nguyen & Hsiang-Ting Lei & Louis Tung Faat Lai & Marc J. Gallenito & Xuelang Mu & Doreen Matthies & Tamir Gonen, 2023. "Lipid flipping in the omega-3 fatty-acid transporter," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    6. Risha Amarsi & Samuel Furse & Mary A. M. Cleaton & Sarah Maurel & Alice L. Mitchell & Anne C. Ferguson-Smith & Nicolas Cenac & Catherine Williamson & Albert Koulman & Marika Charalambous, 2024. "A co-ordinated transcriptional programme in the maternal liver supplies long chain polyunsaturated fatty acids to the conceptus using phospholipids," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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