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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Author

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  • Joseph D. Mancias

    (Dana-Farber Cancer Institute
    Harvard Medical School
    Harvard Radiation Oncology Program
    Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Xiaoxu Wang

    (Dana-Farber Cancer Institute)

  • Steven P. Gygi

    (Harvard Medical School)

  • J. Wade Harper

    (Harvard Medical School)

  • Alec C. Kimmelman

    (Dana-Farber Cancer Institute)

Abstract

Through a quantitative proteomics analysis, a cohort of proteins is identified that associate with autophagosomes, among them a new cargo receptor called NCOA4 that, in response to iron deprivation, targets ferritin to autophagosomes and thereby releases iron.

Suggested Citation

  • Joseph D. Mancias & Xiaoxu Wang & Steven P. Gygi & J. Wade Harper & Alec C. Kimmelman, 2014. "Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy," Nature, Nature, vol. 509(7498), pages 105-109, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7498:d:10.1038_nature13148
    DOI: 10.1038/nature13148
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    1. Dan Fu & Wenming Wang & Yan Zhang & Fan Zhang & Pinyi Yang & Chun Yang & Yufei Tian & Renqi Yao & Jingwu Jian & Zixian Sun & Nan Zhang & Zhiyu Ni & Zihe Rao & Lei Zhao & Yu Guo, 2024. "Self-assembling nanoparticle engineered from the ferritinophagy complex as a rabies virus vaccine candidate," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Di-Yang Sun & Wen-Bin Wu & Jian-Jin Wu & Yu Shi & Jia-Jun Xu & Shen-Xi Ouyang & Chen Chi & Yi Shi & Qing-Xin Ji & Jin-Hao Miao & Jiang-Tao Fu & Jie Tong & Ping-Ping Zhang & Jia-Bao Zhang & Zhi-Yong Li, 2024. "Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    3. Fabian Hoelzgen & Thuy T. P. Nguyen & Elina Klukin & Mohamed Boumaiza & Ayush K. Srivastava & Elizabeth Y. Kim & Ran Zalk & Anat Shahar & Sagit Cohen-Schwartz & Esther G. Meyron-Holtz & Fadi Bou-Abdal, 2024. "Structural basis for the intracellular regulation of ferritin degradation," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    4. Emmanouela Kallergi & Akrivi-Dimitra Daskalaki & Angeliki Kolaxi & Come Camus & Evangelia Ioannou & Valentina Mercaldo & Per Haberkant & Frank Stein & Kyriaki Sidiropoulou & Yannis Dalezios & Mikhail , 2022. "Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice," Nature Communications, Nature, vol. 13(1), pages 1-23, December.
    5. Xiaoting Zhou & You-Kyung Lee & Xianting Li & Henry Kim & Carlos Sanchez-Priego & Xian Han & Haiyan Tan & Suiping Zhou & Yingxue Fu & Kerry Purtell & Qian Wang & Gay R. Holstein & Beisha Tang & Junmin, 2024. "Integrated proteomics reveals autophagy landscape and an autophagy receptor controlling PKA-RI complex homeostasis in neurons," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    6. Xinyi Shan & Jiahuan Li & Jiahao Liu & Baoli Feng & Ting Zhang & Qian Liu & Huixin Ma & Honghong Wu & Hao Wu, 2023. "Targeting ferroptosis by poly(acrylic) acid coated Mn3O4 nanoparticles alleviates acute liver injury," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    7. Wei Yang & Bo Mu & Jing You & Chenyu Tian & Huachao Bin & Zhiqiang Xu & Liting Zhang & Ronggang Ma & Ming Wu & Guo Zhang & Chong Huang & Linli Li & Zhenhua Shao & Lunzhi Dai & Laurent Désaubry & Sheng, 2022. "Non-classical ferroptosis inhibition by a small molecule targeting PHB2," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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