IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v508y2014i7497d10.1038_nature13203.html
   My bibliography  Save this article

Juno is the egg Izumo receptor and is essential for mammalian fertilization

Author

Listed:
  • Enrica Bianchi

    (Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK)

  • Brendan Doe

    (Mouse Production Team, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK)

  • David Goulding

    (Electron and Advanced Light Microscopy Suite, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK)

  • Gavin J. Wright

    (Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK)

Abstract

Fertilization occurs when sperm and egg recognize each other and fuse to form a new, genetically distinct organism. The molecular basis of sperm–egg recognition is unknown, but is likely to require interactions between receptor proteins displayed on their surface. Izumo1 is an essential sperm cell-surface protein, but its receptor on the egg has not been described. Here we identify folate receptor 4 (Folr4) as the receptor for Izumo1 on the mouse egg, and propose to rename it Juno. We show that the Izumo1–Juno interaction is conserved within several mammalian species, including humans. Female mice lacking Juno are infertile and Juno-deficient eggs do not fuse with normal sperm. Rapid shedding of Juno from the oolemma after fertilization suggests a mechanism for the membrane block to polyspermy, ensuring eggs normally fuse with just a single sperm. Our discovery of an essential receptor pair at the nexus of conception provides opportunities for the rational development of new fertility treatments and contraceptives.

Suggested Citation

  • Enrica Bianchi & Brendan Doe & David Goulding & Gavin J. Wright, 2014. "Juno is the egg Izumo receptor and is essential for mammalian fertilization," Nature, Nature, vol. 508(7497), pages 483-487, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7497:d:10.1038_nature13203
    DOI: 10.1038/nature13203
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13203
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13203?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Krista R. B. Gert & Karin Panser & Joachim Surm & Benjamin S. Steinmetz & Alexander Schleiffer & Luca Jovine & Yehu Moran & Fyodor Kondrashov & Andrea Pauli, 2023. "Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Ngonput Agnes Elad & Zelli Riccardo & Menchetti Laura & Sylla Lakamy & Crociati Martina & Monaci Maurizio & Stradaioli Giuseppe, 2020. "Dose and Time Dependent Effect of N-Acetyl-LCysteine Supplementation on In Vitro Fertilization of Bovine Oocytes," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 27(3), pages 20818-20823, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:508:y:2014:i:7497:d:10.1038_nature13203. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.