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Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Author

Listed:
  • Pengda Liu

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Michael Begley

    (Beth Israel Deaconess Medical Center
    Harvard Medical School)

  • Wojciech Michowski

    (Harvard Medical School)

  • Hiroyuki Inuzuka

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Miriam Ginzberg

    (Harvard Medical School)

  • Daming Gao

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Peiling Tsou

    (Beth Israel Deaconess Medical Center
    Harvard Medical School)

  • Wenjian Gan

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Antonella Papa

    (Beth Israel Deaconess Medical Center, Harvard Medical School
    Beth Israel Deaconess Medical Center
    Beth Israel Deaconess Medical Center)

  • Byeong Mo Kim

    (Beth Israel Deaconess Medical Center)

  • Lixin Wan

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Amrik Singh

    (Cell Signaling Technology)

  • Bo Zhai

    (Harvard Medical School)

  • Min Yuan

    (Beth Israel Deaconess Medical Center)

  • Zhiwei Wang

    (Beth Israel Deaconess Medical Center, Harvard Medical School
    Present addresses: The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, China (Z.W.); Cancer Center at Weill Cornell Medical College and NewYork-Presbyterian Hospital, New York, New York 10065, USA (L.C.).)

  • Steven P. Gygi

    (Harvard Medical School)

  • Tae Ho Lee

    (Beth Israel Deaconess Medical Center)

  • Kun-Ping Lu

    (Beth Israel Deaconess Medical Center)

  • Alex Toker

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Pier Paolo Pandolfi

    (Beth Israel Deaconess Medical Center, Harvard Medical School
    Beth Israel Deaconess Medical Center
    Beth Israel Deaconess Medical Center)

  • John M. Asara

    (Beth Israel Deaconess Medical Center)

  • Marc W. Kirschner

    (Harvard Medical School)

  • Piotr Sicinski

    (Harvard Medical School)

  • Lewis Cantley

    (Beth Israel Deaconess Medical Center
    Harvard Medical School
    Present addresses: The Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, China (Z.W.); Cancer Center at Weill Cornell Medical College and NewYork-Presbyterian Hospital, New York, New York 10065, USA (L.C.).)

  • Wenyi Wei

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

Abstract

Phosphorylation of Akt at its carboxy-terminal tail is an essential layer of Akt activation to regulate its physiological functions.

Suggested Citation

  • Pengda Liu & Michael Begley & Wojciech Michowski & Hiroyuki Inuzuka & Miriam Ginzberg & Daming Gao & Peiling Tsou & Wenjian Gan & Antonella Papa & Byeong Mo Kim & Lixin Wan & Amrik Singh & Bo Zhai & M, 2014. "Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus," Nature, Nature, vol. 508(7497), pages 541-545, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7497:d:10.1038_nature13079
    DOI: 10.1038/nature13079
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    Cited by:

    1. Le Yu & Yu Deng & Xiaodong Wang & Charlene Santos & Ian J. Davis & H. Shelton Earp & Pengda Liu, 2024. "Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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