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Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

Author

Listed:
  • Yilong Li

    (Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • Claire Schwab

    (Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK)

  • Sarra L. Ryan

    (Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK)

  • Elli Papaemmanuil

    (Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • Hazel M. Robinson

    (West Midlands Regional Genetics Laboratory, Birmingham Women’s NHS Foundation Trust, Birmingham B15 2TG, UK)

  • Patricia Jacobs

    (Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury SP2 8BJ, UK)

  • Anthony V. Moorman

    (Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK)

  • Sara Dyer

    (West Midlands Regional Genetics Laboratory, Birmingham Women’s NHS Foundation Trust, Birmingham B15 2TG, UK
    School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK)

  • Julian Borrow

    (West Midlands Regional Genetics Laboratory, Birmingham Women’s NHS Foundation Trust, Birmingham B15 2TG, UK
    School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK)

  • Mike Griffiths

    (West Midlands Regional Genetics Laboratory, Birmingham Women’s NHS Foundation Trust, Birmingham B15 2TG, UK
    School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK)

  • Nyla A. Heerema

    (The Ohio State University)

  • Andrew J. Carroll

    (University of Alabama at Birmingham)

  • Polly Talley

    (Sheffield Diagnostic Genetics Service, Sheffield Children’s NHS Foundation Trust, Sheffield S10 2TH, UK)

  • Nick Bown

    (Cytogenetics Laboratory, Northern Genetics Service, Newcastle upon Tyne NE7 7DN, UK)

  • Nick Telford

    (Oncology Cytogenetics, The Christie NHS Foundation Trust, Manchester M20 4BX, UK)

  • Fiona M. Ross

    (Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury SP2 8BJ, UK)

  • Lorraine Gaunt

    (Regional Cytogenetics Unit, Genetic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Saint Mary’s Hospital, Manchester M13 9WL, UK)

  • Richard J. Q. McNally

    (Institute of Health and Society, Newcastle University, Newcastle upon Tyne NE2 4AX, UK)

  • Bryan D. Young

    (Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK)

  • Paul Sinclair

    (Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK)

  • Vikki Rand

    (Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK)

  • Manuel R. Teixeira

    (Portuguese Oncology Institute, Porto University, 4200-072 Porto, Portugal
    Biomedical Sciences Institute (ICBAS), Porto University, 4200-072 Porto, Portugal)

  • Olivia Joseph

    (Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • Ben Robinson

    (Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • Mark Maddison

    (Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • Nicole Dastugue

    (Laboratoire d’Hématologie, Génétique des Hémopathies, Hôpital Purpan, 31059 Toulouse, France)

  • Peter Vandenberghe

    (Center for Human Genetics, University Hospital Leuven, 3000 Leuven, Belgium
    KU Leuven, 3000 Leuven, Belgium)

  • Claudia Haferlach

    (MLL Munich Leukemia Laboratory, Munich 81377, Germany)

  • Philip J. Stephens

    (Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • Jiqiu Cheng

    (Center for Human Genetics, University Hospital Leuven, 3000 Leuven, Belgium
    KU Leuven, 3000 Leuven, Belgium
    University of Leuven, 3000 Leuven, Belgium)

  • Peter Van Loo

    (Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Center for Human Genetics, University Hospital Leuven, 3000 Leuven, Belgium
    KU Leuven, 3000 Leuven, Belgium)

  • Michael R. Stratton

    (Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK)

  • Peter J. Campbell

    (Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    University of Cambridge, Cambridge CB2 2XY, UK)

  • Christine J. Harrison

    (Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK)

Abstract

A rare constitutional translocation between chromosomes 15 and 21 predisposes to catastrophic chromosomal damage followed by amplification of megabase regions, causing a specific subtype of acute lymphoblastic leukaemia.

Suggested Citation

  • Yilong Li & Claire Schwab & Sarra L. Ryan & Elli Papaemmanuil & Hazel M. Robinson & Patricia Jacobs & Anthony V. Moorman & Sara Dyer & Julian Borrow & Mike Griffiths & Nyla A. Heerema & Andrew J. Carr, 2014. "Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia," Nature, Nature, vol. 508(7494), pages 98-102, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7494:d:10.1038_nature13115
    DOI: 10.1038/nature13115
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    Cited by:

    1. Chaohui Li & Lingxi Chen & Guangze Pan & Wenqian Zhang & Shuai Cheng Li, 2023. "Deciphering complex breakage-fusion-bridge genome rearrangements with Ambigram," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Eva G. Álvarez & Jonas Demeulemeester & Paula Otero & Clemency Jolly & Daniel García-Souto & Ana Pequeño-Valtierra & Jorge Zamora & Marta Tojo & Javier Temes & Adrian Baez-Ortega & Bernardo Rodriguez-, 2021. "Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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