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Structure-based programming of lymph-node targeting in molecular vaccines

Author

Listed:
  • Haipeng Liu

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Kelly D. Moynihan

    (Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Yiran Zheng

    (Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Gregory L. Szeto

    (Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Adrienne V. Li

    (Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Bonnie Huang

    (Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Debra S. Van Egeren

    (Massachusetts Institute of Technology)

  • Clara Park

    (Massachusetts Institute of Technology)

  • Darrell J. Irvine

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard)

Abstract

An amphiphile vaccine consisting of a peptide antigen or adjuvant cargo linked to a lipophilic tail is shown to have improved potency and safety in mice by targeting the lymph nodes.

Suggested Citation

  • Haipeng Liu & Kelly D. Moynihan & Yiran Zheng & Gregory L. Szeto & Adrienne V. Li & Bonnie Huang & Debra S. Van Egeren & Clara Park & Darrell J. Irvine, 2014. "Structure-based programming of lymph-node targeting in molecular vaccines," Nature, Nature, vol. 507(7493), pages 519-522, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7493:d:10.1038_nature12978
    DOI: 10.1038/nature12978
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    Cited by:

    1. Shenqiang Wang & Ying Zhang & Yanfang Wang & Yinxian Yang & Sheng Zhao & Tao Sheng & Yuqi Zhang & Zhen Gu & Jinqiang Wang & Jicheng Yu, 2023. "An in situ dual-anchoring strategy for enhanced immobilization of PD-L1 to treat autoimmune diseases," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Vijayendra Dasari & Lisa K. McNeil & Kirrilee Beckett & Matthew Solomon & George Ambalathingal & T. Le Thuy & Archana Panikkar & Caitlyn Smith & Martin P. Steinbuck & Aniela Jakubowski & Lochana M. Se, 2023. "Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Brian D. Ross & Youngsoon Jang & Amanda Welton & Christopher A. Bonham & Dilrukshika S. W. Palagama & Kevin Heist & Jagadish Boppisetti & Kasun P. Imaduwage & Tanner Robison & Leah R. King & Edward Z., 2022. "A lymphatic-absorbed multi-targeted kinase inhibitor for myelofibrosis therapy," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Ella N. Hoogenboezem & Shrusti S. Patel & Justin H. Lo & Ashley B. Cavnar & Lauren M. Babb & Nora Francini & Eva F. Gbur & Prarthana Patil & Juan M. Colazo & Danielle L. Michell & Violeta M. Sanchez &, 2024. "Structural optimization of siRNA conjugates for albumin binding achieves effective MCL1-directed cancer therapy," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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