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A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium

Author

Listed:
  • Abhinav Sinha

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

  • Katie R. Hughes

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

  • Katarzyna K. Modrzynska

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Thomas D. Otto

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Claudia Pfander

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Nicholas J. Dickens

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

  • Agnieszka A. Religa

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

  • Ellen Bushell

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Anne L. Graham

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

  • Rachael Cameron

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

  • Bjorn F. C. Kafsack

    (Princeton University)

  • April E. Williams

    (Princeton University
    Lewis-Sigler Institute for Integrative Genomics, Princeton University)

  • Manuel Llinás

    (Princeton University
    Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Present address: Department of Biochemistry and Molecular Biology and Center for Infectious Disease Dynamics, The Pennsylvania State University, State College, Pennsylvania 16802, USA.)

  • Matthew Berriman

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Oliver Billker

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Andrew P. Waters

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

Abstract

Malaria parasites must produce gametocytes for transmission to the mosquito vector, although the molecular mechanisms underlying commitment to gametocyte production remain unclear; here this process is found to be controlled by PbAP2-G, a member of the ApiAP2 family of DNA-binding proteins, in the rodent-infecting Plasmodium berghei parasite.

Suggested Citation

  • Abhinav Sinha & Katie R. Hughes & Katarzyna K. Modrzynska & Thomas D. Otto & Claudia Pfander & Nicholas J. Dickens & Agnieszka A. Religa & Ellen Bushell & Anne L. Graham & Rachael Cameron & Bjorn F. C, 2014. "A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium," Nature, Nature, vol. 507(7491), pages 253-257, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7491:d:10.1038_nature12970
    DOI: 10.1038/nature12970
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    Cited by:

    1. Jin-Lei Wang & Ting-Ting Li & Nian-Zhang Zhang & Meng Wang & Li-Xiu Sun & Zhi-Wei Zhang & Bao-Quan Fu & Hany M. Elsheikha & Xing-Quan Zhu, 2024. "The transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Jiepeng Guan & Peijia Wu & Xiaoli Mo & Xiaolong Zhang & Wenqi Liang & Xiaoming Zhang & Lubin Jiang & Jian Li & Huiting Cui & Jing Yuan, 2024. "An axonemal intron splicing program sustains Plasmodium male development," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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