IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v507y2014i7491d10.1038_nature12970.html
   My bibliography  Save this article

A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium

Author

Listed:
  • Abhinav Sinha

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

  • Katie R. Hughes

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

  • Katarzyna K. Modrzynska

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Thomas D. Otto

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Claudia Pfander

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Nicholas J. Dickens

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

  • Agnieszka A. Religa

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

  • Ellen Bushell

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Anne L. Graham

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

  • Rachael Cameron

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

  • Bjorn F. C. Kafsack

    (Princeton University)

  • April E. Williams

    (Princeton University
    Lewis-Sigler Institute for Integrative Genomics, Princeton University)

  • Manuel Llinás

    (Princeton University
    Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Present address: Department of Biochemistry and Molecular Biology and Center for Infectious Disease Dynamics, The Pennsylvania State University, State College, Pennsylvania 16802, USA.)

  • Matthew Berriman

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Oliver Billker

    (Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK)

  • Andrew P. Waters

    (Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK)

Abstract

Malaria parasites must produce gametocytes for transmission to the mosquito vector, although the molecular mechanisms underlying commitment to gametocyte production remain unclear; here this process is found to be controlled by PbAP2-G, a member of the ApiAP2 family of DNA-binding proteins, in the rodent-infecting Plasmodium berghei parasite.

Suggested Citation

  • Abhinav Sinha & Katie R. Hughes & Katarzyna K. Modrzynska & Thomas D. Otto & Claudia Pfander & Nicholas J. Dickens & Agnieszka A. Religa & Ellen Bushell & Anne L. Graham & Rachael Cameron & Bjorn F. C, 2014. "A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium," Nature, Nature, vol. 507(7491), pages 253-257, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7491:d:10.1038_nature12970
    DOI: 10.1038/nature12970
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12970
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12970?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jin-Lei Wang & Ting-Ting Li & Nian-Zhang Zhang & Meng Wang & Li-Xiu Sun & Zhi-Wei Zhang & Bao-Quan Fu & Hany M. Elsheikha & Xing-Quan Zhu, 2024. "The transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Jiepeng Guan & Peijia Wu & Xiaoli Mo & Xiaolong Zhang & Wenqi Liang & Xiaoming Zhang & Lubin Jiang & Jian Li & Huiting Cui & Jing Yuan, 2024. "An axonemal intron splicing program sustains Plasmodium male development," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Brittany Hazzard & Juliana M. Sá & Haikel N. Bogale & Tales V. Pascini & Angela C. Ellis & Shuchi Amin & Jennifer S. Armistead & John H. Adams & Thomas E. Wellems & David Serre, 2024. "Single-cell analyses of polyclonal Plasmodium vivax infections and their consequences on parasite transmission," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:507:y:2014:i:7491:d:10.1038_nature12970. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.