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SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation

Author

Listed:
  • Lianna M. Johnson

    (Cell and Developmental Biology, University of California at Los Angeles)

  • Jiamu Du

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Christopher J. Hale

    (Cell and Developmental Biology, University of California at Los Angeles)

  • Sylvain Bischof

    (Cell and Developmental Biology, University of California at Los Angeles)

  • Suhua Feng

    (Cell and Developmental Biology, University of California at Los Angeles
    Howard Hughes Medical Institute, University of California at Los Angeles)

  • Ramakrishna K. Chodavarapu

    (Cell and Developmental Biology, University of California at Los Angeles)

  • Xuehua Zhong

    (Cell and Developmental Biology, University of California at Los Angeles
    Present address: Wisconsin Institute for Discovery, Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA.)

  • Giuseppe Marson

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Matteo Pellegrini

    (Cell and Developmental Biology, University of California at Los Angeles)

  • David J. Segal

    (University of California at Davis)

  • Dinshaw J. Patel

    (Structural Biology Program, Memorial Sloan-Kettering Cancer Center)

  • Steven E. Jacobsen

    (Cell and Developmental Biology, University of California at Los Angeles
    Howard Hughes Medical Institute, University of California at Los Angeles)

Abstract

In Arabidopsis, the RNA-directed DNA methylation pathway is important for establishing and maintaining DNA methylation — here Pol V is shown to depend on SUVH2 and SUVH9, where both of these proteins are proposed to bind specifically to methylated DNA to recruit Pol V, providing a self-reinforcing loop mechanism for maintenance of RNA-directed DNA methylation.

Suggested Citation

  • Lianna M. Johnson & Jiamu Du & Christopher J. Hale & Sylvain Bischof & Suhua Feng & Ramakrishna K. Chodavarapu & Xuehua Zhong & Giuseppe Marson & Matteo Pellegrini & David J. Segal & Dinshaw J. Patel , 2014. "SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation," Nature, Nature, vol. 507(7490), pages 124-128, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7490:d:10.1038_nature12931
    DOI: 10.1038/nature12931
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    Cited by:

    1. Hong-Wei Zhang & Kun Huang & Zhan-Xi Gu & Xiao-Xian Wu & Jia-Wei Wang & Yu Zhang, 2023. "A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Zheng Li & Ming Wang & Zhenhui Zhong & Javier Gallego-Bartolomé & Suhua Feng & Yasaman Jami-Alahmadi & Xinyi Wang & James Wohlschlegel & Sylvain Bischof & Jeff A. Long & Steven E. Jacobsen, 2023. "The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Yinwen Zhang & Hosung Jang & Rui Xiao & Ioanna Kakoulidou & Robert S. Piecyk & Frank Johannes & Robert J. Schmitz, 2021. "Heterochromatin is a quantitative trait associated with spontaneous epiallele formation," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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