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Structural basis of the alternating-access mechanism in a bile acid transporter

Author

Listed:
  • Xiaoming Zhou

    (Baylor College of Medicine
    Columbia University)

  • Elena J. Levin

    (Baylor College of Medicine)

  • Yaping Pan

    (Baylor College of Medicine)

  • Jason G. McCoy

    (Baylor College of Medicine)

  • Ruchika Sharma

    (Columbia University)

  • Brian Kloss

    (New York Consortium on Membrane Protein Structure)

  • Renato Bruni

    (New York Consortium on Membrane Protein Structure)

  • Matthias Quick

    (Columbia University
    New York State Psychiatric Institute)

  • Ming Zhou

    (Baylor College of Medicine
    Columbia University
    Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China)

Abstract

Inhibitors of the bile acid transporter ASBT may be useful therapeutics for treating hypercholesterolaemia and type 2 diabetes; here, two X-ray crystal structures of an ASBT homologue from Yersinia frederiksenii are solved.

Suggested Citation

  • Xiaoming Zhou & Elena J. Levin & Yaping Pan & Jason G. McCoy & Ruchika Sharma & Brian Kloss & Renato Bruni & Matthias Quick & Ming Zhou, 2014. "Structural basis of the alternating-access mechanism in a bile acid transporter," Nature, Nature, vol. 505(7484), pages 569-573, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7484:d:10.1038_nature12811
    DOI: 10.1038/nature12811
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    Cited by:

    1. Yao Zhang & Yuhan Jiang & Kaifu Gao & Dexin Sui & Peixuan Yu & Min Su & Guo-Wei Wei & Jian Hu, 2023. "Structural insights into the elevator-type transport mechanism of a bacterial ZIP metal transporter," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Yongzhen Liu & Thomas R. Cafiero & Debby Park & Abhishek Biswas & Benjamin Y. Winer & Cheul H. Cho & Yaron Bram & Vasuretha Chandar & Aoife K. O’ Connell & Hans P. Gertje & Nicholas Crossland & Robert, 2023. "Targeted viral adaptation generates a simian-tropic hepatitis B virus that infects marmoset cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Fuhui Meng & Yang Xiao & Yujia Ji & Ziyi Sun & Xiaoming Zhou, 2022. "An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Martin F. Peter & Jan A. Ruland & Peer Depping & Niels Schneberger & Emmanuele Severi & Jonas Moecking & Karl Gatterdam & Sarah Tindall & Alexandre Durand & Veronika Heinz & Jan Peter Siebrasse & Paul, 2022. "Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporter," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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