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Distinct fibroblast lineages determine dermal architecture in skin development and repair

Author

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  • Ryan R. Driskell

    (Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge CB2 1QR, UK
    Centre for Stem Cells and Regenerative Medicine, King’s College London, 28th floor, Tower Wing, Guy’s Hospital, London SE1 9RT, UK)

  • Beate M. Lichtenberger

    (Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge CB2 1QR, UK
    Centre for Stem Cells and Regenerative Medicine, King’s College London, 28th floor, Tower Wing, Guy’s Hospital, London SE1 9RT, UK)

  • Esther Hoste

    (Centre for Stem Cells and Regenerative Medicine, King’s College London, 28th floor, Tower Wing, Guy’s Hospital, London SE1 9RT, UK
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Kai Kretzschmar

    (Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge CB2 1QR, UK
    Centre for Stem Cells and Regenerative Medicine, King’s College London, 28th floor, Tower Wing, Guy’s Hospital, London SE1 9RT, UK)

  • Ben D. Simons

    (Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, UK)

  • Marika Charalambous

    (Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK)

  • Sacri R. Ferron

    (Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK)

  • Yann Herault

    (Institut Clinique de la Souris, Parc d’Innovation, 67404 Illkrich-Graffenstaden, Cedex, France)

  • Guillaume Pavlovic

    (Institut Clinique de la Souris, Parc d’Innovation, 67404 Illkrich-Graffenstaden, Cedex, France)

  • Anne C. Ferguson-Smith

    (Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK)

  • Fiona M. Watt

    (Centre for Stem Cells and Regenerative Medicine, King’s College London, 28th floor, Tower Wing, Guy’s Hospital, London SE1 9RT, UK)

Abstract

Fibroblasts constitute the major mesenchymal cell type in the connective tissue and their functions are remarkably diverse: here, by characterising lineages of mouse skin fibroblasts, it is shown that distinct subpopulations contribute to skin development and repair during injury.

Suggested Citation

  • Ryan R. Driskell & Beate M. Lichtenberger & Esther Hoste & Kai Kretzschmar & Ben D. Simons & Marika Charalambous & Sacri R. Ferron & Yann Herault & Guillaume Pavlovic & Anne C. Ferguson-Smith & Fiona , 2013. "Distinct fibroblast lineages determine dermal architecture in skin development and repair," Nature, Nature, vol. 504(7479), pages 277-281, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7479:d:10.1038_nature12783
    DOI: 10.1038/nature12783
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    Citations

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    Cited by:

    1. Xiaojie Cai & Maoying Han & Fangzhou Lou & Yang Sun & Qianqian Yin & Libo Sun & Zhikai Wang & Xiangxiao Li & Hong Zhou & Zhenyao Xu & Hong Wang & Siyu Deng & Xichen Zheng & Taiyu Zhang & Qun Li & Bin , 2023. "Tenascin C+ papillary fibroblasts facilitate neuro-immune interaction in a mouse model of psoriasis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Martin Arostegui & R. Wilder Scott & Kerstin Böse & T. Michael Underhill, 2022. "Cellular taxonomy of Hic1+ mesenchymal progenitor derivatives in the limb: from embryo to adult," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Greg Holmes & Ana S. Gonzalez-Reiche & Madrikha Saturne & Susan M. Motch Perrine & Xianxiao Zhou & Ana C. Borges & Bhavana Shewale & Joan T. Richtsmeier & Bin Zhang & Harm Bakel & Ethylin Wang Jabs, 2021. "Single-cell analysis identifies a key role for Hhip in murine coronal suture development," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    4. Agnes Forsthuber & Bertram Aschenbrenner & Ana Korosec & Tina Jacob & Karl Annusver & Natalia Krajic & Daria Kholodniuk & Sophie Frech & Shaohua Zhu & Kim Purkhauser & Katharina Lipp & Franziska Werne, 2024. "Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    5. Simone Isling Pærregaard & Line Wulff & Sophie Schussek & Kristoffer Niss & Urs Mörbe & Johan Jendholm & Kerstin Wendland & Anna T. Andrusaite & Kevin F. Brulois & Robert J. B. Nibbs & Katarzyna Sitni, 2023. "The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1+ precursors," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    6. Urban Lendahl & Lars Muhl & Christer Betsholtz, 2022. "Identification, discrimination and heterogeneity of fibroblasts," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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