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Derivation of novel human ground state naive pluripotent stem cells

Author

Listed:
  • Ohad Gafni

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Leehee Weinberger

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Abed AlFatah Mansour

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Yair S. Manor

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Elad Chomsky

    (Weizmann Institute of Science, Rehovot 76100, Israel
    Weizmann Institute of Science, Rehovot 76100, Israel
    Weizmann Institute of Science, Rehovot 76100, Israel)

  • Dalit Ben-Yosef

    (Wolfe PGD Stem Cell Lab, Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center
    Sackler Medical School, Tel-Aviv University)

  • Yael Kalma

    (Wolfe PGD Stem Cell Lab, Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center)

  • Sergey Viukov

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Itay Maza

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Asaf Zviran

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Yoach Rais

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Zohar Shipony

    (Weizmann Institute of Science, Rehovot 76100, Israel
    Weizmann Institute of Science, Rehovot 76100, Israel)

  • Zohar Mukamel

    (Weizmann Institute of Science, Rehovot 76100, Israel
    Weizmann Institute of Science, Rehovot 76100, Israel)

  • Vladislav Krupalnik

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Mirie Zerbib

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Shay Geula

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Inbal Caspi

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Dan Schneir

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Tamar Shwartz

    (Wolfe PGD Stem Cell Lab, Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center)

  • Shlomit Gilad

    (The Israel National Center for Personalized Medicine (INCPM), Weizmann Institute of Science, Rehovot 76100, Israel)

  • Daniela Amann-Zalcenstein

    (The Israel National Center for Personalized Medicine (INCPM), Weizmann Institute of Science, Rehovot 76100, Israel)

  • Sima Benjamin

    (The Israel National Center for Personalized Medicine (INCPM), Weizmann Institute of Science, Rehovot 76100, Israel)

  • Ido Amit

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Amos Tanay

    (Weizmann Institute of Science, Rehovot 76100, Israel
    Weizmann Institute of Science, Rehovot 76100, Israel)

  • Rada Massarwa

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Noa Novershtern

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Jacob H. Hanna

    (Weizmann Institute of Science, Rehovot 76100, Israel)

Abstract

It is known that human embryonic stem (ES) cells are more similar to mouse primed epiblast stem cells than to naive mouse ES cells; here culture conditions are determined that allow human ES and induced pluripotent stem cells to acquire a pluripotent state that retains growth characteristics highly similar to mouse naive ES cells, and competence in generating cross-species human-mouse embryonic chimaerism.

Suggested Citation

  • Ohad Gafni & Leehee Weinberger & Abed AlFatah Mansour & Yair S. Manor & Elad Chomsky & Dalit Ben-Yosef & Yael Kalma & Sergey Viukov & Itay Maza & Asaf Zviran & Yoach Rais & Zohar Shipony & Zohar Mukam, 2013. "Derivation of novel human ground state naive pluripotent stem cells," Nature, Nature, vol. 504(7479), pages 282-286, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7479:d:10.1038_nature12745
    DOI: 10.1038/nature12745
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    Citations

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    Cited by:

    1. Marissa Cloutier & Surinder Kumar & Emily Buttigieg & Laura Keller & Brandon Lee & Aaron Williams & Sandra Mojica-Perez & Indri Erliandri & Andre Monteiro Da Rocha & Kenneth Cadigan & Gary D. Smith & , 2022. "Preventing erosion of X-chromosome inactivation in human embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Yan Bi & Zhifen Tu & Jianfeng Zhou & Xuehao Zhu & Hong Wang & Shaorong Gao & Yixuan Wang, 2022. "Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Aditya Kshirsagar & Svetlana Maslov Doroshev & Anna Gorelik & Tsviya Olender & Tamar Sapir & Daisuke Tsuboi & Irit Rosenhek-Goldian & Sergey Malitsky & Maxim Itkin & Amir Argoetti & Yael Mandel-Gutfre, 2023. "LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Kirstin Meyer & Nicholas C. Lammers & Lukasz J. Bugaj & Hernan G. Garcia & Orion D. Weiner, 2023. "Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    5. Yinuo Wang & Adel Elsherbiny & Linda Kessler & Julio Cordero & Haojie Shi & Heike Serke & Olga Lityagina & Felix A. Trogisch & Mona Malek Mohammadi & Ibrahim El-Battrawy & Johannes Backs & Thomas Wiel, 2022. "Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function," Nature Communications, Nature, vol. 13(1), pages 1-24, December.
    6. Woranop Sukparangsi & Elena Morganti & Molly Lowndes & Hélène Mayeur & Melanie Weisser & Fella Hammachi & Hanna Peradziryi & Fabian Roske & Jurriaan Hölzenspies & Alessandra Livigni & Benoit Gilbert G, 2022. "Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

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