IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v504y2013i7479d10.1038_nature12745.html
   My bibliography  Save this article

Derivation of novel human ground state naive pluripotent stem cells

Author

Listed:
  • Ohad Gafni

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Leehee Weinberger

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Abed AlFatah Mansour

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Yair S. Manor

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Elad Chomsky

    (Weizmann Institute of Science, Rehovot 76100, Israel
    Weizmann Institute of Science, Rehovot 76100, Israel
    Weizmann Institute of Science, Rehovot 76100, Israel)

  • Dalit Ben-Yosef

    (Wolfe PGD Stem Cell Lab, Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center
    Sackler Medical School, Tel-Aviv University)

  • Yael Kalma

    (Wolfe PGD Stem Cell Lab, Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center)

  • Sergey Viukov

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Itay Maza

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Asaf Zviran

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Yoach Rais

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Zohar Shipony

    (Weizmann Institute of Science, Rehovot 76100, Israel
    Weizmann Institute of Science, Rehovot 76100, Israel)

  • Zohar Mukamel

    (Weizmann Institute of Science, Rehovot 76100, Israel
    Weizmann Institute of Science, Rehovot 76100, Israel)

  • Vladislav Krupalnik

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Mirie Zerbib

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Shay Geula

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Inbal Caspi

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Dan Schneir

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Tamar Shwartz

    (Wolfe PGD Stem Cell Lab, Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center)

  • Shlomit Gilad

    (The Israel National Center for Personalized Medicine (INCPM), Weizmann Institute of Science, Rehovot 76100, Israel)

  • Daniela Amann-Zalcenstein

    (The Israel National Center for Personalized Medicine (INCPM), Weizmann Institute of Science, Rehovot 76100, Israel)

  • Sima Benjamin

    (The Israel National Center for Personalized Medicine (INCPM), Weizmann Institute of Science, Rehovot 76100, Israel)

  • Ido Amit

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Amos Tanay

    (Weizmann Institute of Science, Rehovot 76100, Israel
    Weizmann Institute of Science, Rehovot 76100, Israel)

  • Rada Massarwa

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Noa Novershtern

    (Weizmann Institute of Science, Rehovot 76100, Israel)

  • Jacob H. Hanna

    (Weizmann Institute of Science, Rehovot 76100, Israel)

Abstract

It is known that human embryonic stem (ES) cells are more similar to mouse primed epiblast stem cells than to naive mouse ES cells; here culture conditions are determined that allow human ES and induced pluripotent stem cells to acquire a pluripotent state that retains growth characteristics highly similar to mouse naive ES cells, and competence in generating cross-species human-mouse embryonic chimaerism.

Suggested Citation

  • Ohad Gafni & Leehee Weinberger & Abed AlFatah Mansour & Yair S. Manor & Elad Chomsky & Dalit Ben-Yosef & Yael Kalma & Sergey Viukov & Itay Maza & Asaf Zviran & Yoach Rais & Zohar Shipony & Zohar Mukam, 2013. "Derivation of novel human ground state naive pluripotent stem cells," Nature, Nature, vol. 504(7479), pages 282-286, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7479:d:10.1038_nature12745
    DOI: 10.1038/nature12745
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12745
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12745?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Aditya Kshirsagar & Svetlana Maslov Doroshev & Anna Gorelik & Tsviya Olender & Tamar Sapir & Daisuke Tsuboi & Irit Rosenhek-Goldian & Sergey Malitsky & Maxim Itkin & Amir Argoetti & Yael Mandel-Gutfre, 2023. "LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Kirstin Meyer & Nicholas C. Lammers & Lukasz J. Bugaj & Hernan G. Garcia & Orion D. Weiner, 2023. "Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Yinuo Wang & Adel Elsherbiny & Linda Kessler & Julio Cordero & Haojie Shi & Heike Serke & Olga Lityagina & Felix A. Trogisch & Mona Malek Mohammadi & Ibrahim El-Battrawy & Johannes Backs & Thomas Wiel, 2022. "Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function," Nature Communications, Nature, vol. 13(1), pages 1-24, December.
    4. Woranop Sukparangsi & Elena Morganti & Molly Lowndes & Hélène Mayeur & Melanie Weisser & Fella Hammachi & Hanna Peradziryi & Fabian Roske & Jurriaan Hölzenspies & Alessandra Livigni & Benoit Gilbert G, 2022. "Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    5. Marissa Cloutier & Surinder Kumar & Emily Buttigieg & Laura Keller & Brandon Lee & Aaron Williams & Sandra Mojica-Perez & Indri Erliandri & Andre Monteiro Da Rocha & Kenneth Cadigan & Gary D. Smith & , 2022. "Preventing erosion of X-chromosome inactivation in human embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    6. Yan Bi & Zhifen Tu & Jianfeng Zhou & Xuehao Zhu & Hong Wang & Shaorong Gao & Yixuan Wang, 2022. "Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:504:y:2013:i:7479:d:10.1038_nature12745. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.