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Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection

Author

Listed:
  • Shokrollah Elahi

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

  • James M. Ertelt

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

  • Jeremy M. Kinder

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

  • Tony T. Jiang

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

  • Xuzhe Zhang

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

  • Lijun Xin

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

  • Vandana Chaturvedi

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

  • Beverly S. Strong

    (Center for Fetal Cellular and Molecular Therapy, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

  • Joseph E. Qualls

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

  • Kris A. Steinbrecher

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

  • Theodosia A. Kalfa

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

  • Aimen F. Shaaban

    (Center for Fetal Cellular and Molecular Therapy, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

  • Sing Sing Way

    (Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA)

Abstract

In neonatal mice, susceptibility to infection is due to an enriched subset of arginase-2-expressing CD71+ erythroid cells, which suppresses the systemic activation of immune cells, thereby protecting neonates against aberrant inflammation triggered by colonization with commensal microbes.

Suggested Citation

  • Shokrollah Elahi & James M. Ertelt & Jeremy M. Kinder & Tony T. Jiang & Xuzhe Zhang & Lijun Xin & Vandana Chaturvedi & Beverly S. Strong & Joseph E. Qualls & Kris A. Steinbrecher & Theodosia A. Kalfa , 2013. "Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection," Nature, Nature, vol. 504(7478), pages 158-162, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7478:d:10.1038_nature12675
    DOI: 10.1038/nature12675
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    Cited by:

    1. EM Ahmed & Marwa Al-Moghazy, 2020. "Microbial Endocrinology- Interaction of the Microbial Hormones with the Host," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 24(2), pages 18052-18054, January.
    2. Chuan Zhang & Lingli Zhang & Xinghui Liu & Li Zhang & Zhiyou Zeng & Lin Li & Guanjian Liu & Hong Jiang, 2015. "Timing of Antibiotic Prophylaxis in Elective Caesarean Delivery: A Multi-Center Randomized Controlled Trial and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-15, July.

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