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The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition

Author

Listed:
  • Brenda L. Bloodgood

    (Harvard Medical School
    University of California San Diego)

  • Nikhil Sharma

    (Harvard Medical School
    Harvard University)

  • Heidi Adlman Browne

    (Harvard Medical School
    Present addresses: Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA (H.A.B.); Department of Neuroscience, Brown University, National Institutes of Health Graduate Partnership Program, Providence, Rhode Island 02912, USA (A.T.).)

  • Alissa Z. Trepman

    (Harvard Medical School
    Present addresses: Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA (H.A.B.); Department of Neuroscience, Brown University, National Institutes of Health Graduate Partnership Program, Providence, Rhode Island 02912, USA (A.T.).)

  • Michael E. Greenberg

    (Harvard Medical School)

Abstract

The transcription factor NPAS4 enables neurons to distinguish synaptic inputs received at their soma or dendrites; sensory stimulation increases NPAS4 which promotes inhibitory synapses on the soma and destabilizes inhibitory synapses on the dendrites.

Suggested Citation

  • Brenda L. Bloodgood & Nikhil Sharma & Heidi Adlman Browne & Alissa Z. Trepman & Michael E. Greenberg, 2013. "The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition," Nature, Nature, vol. 503(7474), pages 121-125, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7474:d:10.1038_nature12743
    DOI: 10.1038/nature12743
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    Cited by:

    1. Brandon W. Hughes & Jessica L. Huebschman & Evgeny Tsvetkov & Benjamin M. Siemsen & Kirsten K. Snyder & Rose Marie Akiki & Daniel J. Wood & Rachel D. Penrod & Michael D. Scofield & Stefano Berto & Mak, 2024. "NPAS4 supports cocaine-conditioned cues in rodents by controlling the cell type-specific activation balance in the nucleus accumbens," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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