IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v503y2013i7474d10.1038_nature12709.html
   My bibliography  Save this article

Cooperation between brain and islet in glucose homeostasis and diabetes

Author

Listed:
  • Michael W. Schwartz

    (Diabetes and Obesity Center of Excellence, University of Washington)

  • Randy J. Seeley

    (University of Cincinnati)

  • Matthias H. Tschöp

    (Institute of Diabetes and Obesity, Technische Universität München, Munich 85764, Germany)

  • Stephen C. Woods

    (University of Cincinnati)

  • Gregory J. Morton

    (Diabetes and Obesity Center of Excellence, University of Washington)

  • Martin G. Myers

    (University of Michigan)

  • David D’Alessio

    (University of Cincinnati)

Abstract

An alternative view of diabetes is presented in which blood glucose homeostasis is achieved via collective actions of two regulatory systems: a brain-centred glucoregulatory system (BCGS), which works together with the pancreatic islets; defects in both systems may be required for diabetes to occur, and interventions targeting both systems may have greater therapeutic potential.

Suggested Citation

  • Michael W. Schwartz & Randy J. Seeley & Matthias H. Tschöp & Stephen C. Woods & Gregory J. Morton & Martin G. Myers & David D’Alessio, 2013. "Cooperation between brain and islet in glucose homeostasis and diabetes," Nature, Nature, vol. 503(7474), pages 59-66, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7474:d:10.1038_nature12709
    DOI: 10.1038/nature12709
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12709
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12709?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Se Hwan Park & Jin Hwan Yoon & Dae Yun Seo & Tae Nyun Kim & Jeong Rim Ko & Jin Han, 2019. "Resistance Exercise Training Attenuates the Loss of Endogenous GLP-1 Receptor in the Hypothalamus of Type 2 Diabetic Rats," IJERPH, MDPI, vol. 16(5), pages 1-11, March.
    2. Andreas Wagner, 2015. "Causal Drift, Robust Signaling, and Complex Disease," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-29, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:503:y:2013:i:7474:d:10.1038_nature12709. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.