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Resistance Exercise Training Attenuates the Loss of Endogenous GLP-1 Receptor in the Hypothalamus of Type 2 Diabetic Rats

Author

Listed:
  • Se Hwan Park

    (Institute of Sports Medicine, Hannam University, Daejeon 34430, Korea)

  • Jin Hwan Yoon

    (Institute of Sports Medicine, Hannam University, Daejeon 34430, Korea)

  • Dae Yun Seo

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea)

  • Tae Nyun Kim

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea)

  • Jeong Rim Ko

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea)

  • Jin Han

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
    Department of Health Science and Technology, Graduate School, Inje University, Busan 47392, Korea)

Abstract

The aim of this study was to investigate the effects of resistance exercise training on hypothalamic GLP-1R levels and its related signaling mechanisms in T2DM. The animals were separated into three groups: a non-diabetic control (CON), diabetic control (DM), and diabetic with resistance exercise (DM + EXE) group. The resistance exercise training group performed ladder climbing (eight repetitions, three days per week for 12 weeks). Body weight was slightly lower in the DM + EXE group than the DM group, but difference between the groups was not significant. Food intake and glucose were significantly lower in the DM + EXE group than in the DM group. The blood insulin concentration was significantly higher and glucagon was significantly lower in the DM + EXE group. The DM + EXE group in the hypothalamus showed significant increases in GLP-1R mRNA, protein kinase A (PKA), glucose transporter 2 (GLUT2), and protein kinase B (AKT) and significant decrease in protein kinase C-iota (PKC-iota). Antioxidant enzymes and apoptosis factors were significantly improved in the DM + EXE group compared with the DM group in the hypothalamus. The results suggest that resistance exercise contributes to improvements the overall health of the brain in diabetic conditions.

Suggested Citation

  • Se Hwan Park & Jin Hwan Yoon & Dae Yun Seo & Tae Nyun Kim & Jeong Rim Ko & Jin Han, 2019. "Resistance Exercise Training Attenuates the Loss of Endogenous GLP-1 Receptor in the Hypothalamus of Type 2 Diabetic Rats," IJERPH, MDPI, vol. 16(5), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:5:p:830-:d:211814
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    References listed on IDEAS

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    1. Michael W. Schwartz & Randy J. Seeley & Matthias H. Tschöp & Stephen C. Woods & Gregory J. Morton & Martin G. Myers & David D’Alessio, 2013. "Cooperation between brain and islet in glucose homeostasis and diabetes," Nature, Nature, vol. 503(7474), pages 59-66, November.
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