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A directional switch of integrin signalling and a new anti-thrombotic strategy

Author

Listed:
  • Bo Shen

    (University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA)

  • Xiaojuan Zhao

    (University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA)

  • Kelly A. O’Brien

    (University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA)

  • Aleksandra Stojanovic-Terpo

    (University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA)

  • M. Keegan Delaney

    (University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA)

  • Kyungho Kim

    (University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA)

  • Jaehyung Cho

    (University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA)

  • Stephen C.-T. Lam

    (University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA)

  • Xiaoping Du

    (University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA)

Abstract

The direction of integrin signalling is found to be determined by the coordinated and opposing binding waves of talin and Gα13 to the same region of the integrin β3 cytoplasmic domain at mutually exclusive but distinct sites, and a potent new anti-thrombotic drug that does not cause bleeding is designed on the basis of these findings.

Suggested Citation

  • Bo Shen & Xiaojuan Zhao & Kelly A. O’Brien & Aleksandra Stojanovic-Terpo & M. Keegan Delaney & Kyungho Kim & Jaehyung Cho & Stephen C.-T. Lam & Xiaoping Du, 2013. "A directional switch of integrin signalling and a new anti-thrombotic strategy," Nature, Nature, vol. 503(7474), pages 131-135, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7474:d:10.1038_nature12613
    DOI: 10.1038/nature12613
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    Cited by:

    1. Yaping Zhang & Xiaojuan Zhao & Bo Shen & Yanyan Bai & Claire Chang & Aleksandra Stojanovic & Can Wang & Andrew Mack & Gary Deng & Randal A. Skidgel & Ni Cheng & Xiaoping Du, 2023. "Integrin β3 directly inhibits the Gα13-p115RhoGEF interaction to regulate G protein signaling and platelet exocytosis," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Yangyang Ding & Xiang Gui & Xiang Chu & Yueyue Sun & Sixuan Zhang & Huan Tong & Wen Ju & Yue Li & Zengtian Sun & Mengdi Xu & Zhenyu Li & Robert K. Andrews & Elizabeth E. Gardiner & Lingyu Zeng & Kaili, 2023. "MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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