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Synthetic non-oxidative glycolysis enables complete carbon conservation

Author

Listed:
  • Igor W. Bogorad

    (University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, California 90095, USA.
    University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, California 90095, USA)

  • Tzu-Shyang Lin

    (University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, California 90095, USA.)

  • James C. Liao

    (University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, California 90095, USA.
    Institute for Genomics and Proteomics, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, California 90095, USA)

Abstract

A non-oxidative, cyclic pathway—termed non-oxidative glycolysis—is designed and constructed that enables complete carbon conservation in sugar catabolism to acetyl-coenzyme A, and can be used to achieve a 100% carbon yield to fuels and chemicals.

Suggested Citation

  • Igor W. Bogorad & Tzu-Shyang Lin & James C. Liao, 2013. "Synthetic non-oxidative glycolysis enables complete carbon conservation," Nature, Nature, vol. 502(7473), pages 693-697, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7473:d:10.1038_nature12575
    DOI: 10.1038/nature12575
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    Cited by:

    1. Tong Wu & Paul A. Gómez-Coronado & Armin Kubis & Steffen N. Lindner & Philippe Marlière & Tobias J. Erb & Arren Bar-Even & Hai He, 2023. "Engineering a synthetic energy-efficient formaldehyde assimilation cycle in Escherichia coli," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Xinlei Wei & Xue Yang & Congcong Hu & Qiangzi Li & Qianqian Liu & Yue Wu & Leipeng Xie & Xiao Ning & Fei Li & Tao Cai & Zhiguang Zhu & Yi-Heng P. Job Zhang & Yanfei Zhang & Xuejun Chen & Chun You, 2024. "ATP-free in vitro biotransformation of starch-derived maltodextrin into poly-3-hydroxybutyrate via acetyl-CoA," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Likun Guo & Min Liu & Yujia Bi & Qingsheng Qi & Mo Xian & Guang Zhao, 2023. "Using a synthetic machinery to improve carbon yield with acetylphosphate as the core," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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