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HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis

Author

Listed:
  • Carrie A. Adelman

    (DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK)

  • Rafal L. Lolo

    (DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK)

  • Nicolai J. Birkbak

    (Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby 2800, Denmark)

  • Olga Murina

    (Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland)

  • Kenichiro Matsuzaki

    (DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK)

  • Zuzana Horejsi

    (DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK)

  • Kalindi Parmar

    (Dana Farber Cancer Institute)

  • Valérie Borel

    (DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK)

  • J. Mark Skehel

    (Protein Analysis and Proteomics Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
    Present address: Mass Spectrometry, Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.)

  • Gordon Stamp

    (Experimental Histopathology Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Alan D’Andrea

    (Dana Farber Cancer Institute)

  • Alessandro A. Sartori

    (Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland)

  • Charles Swanton

    (Translational Cancer Therapeutics Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
    UCL Cancer Institute, Huntley Street, London WC1E 6DD, UK)

  • Simon J. Boulton

    (DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK)

Abstract

Interstrand crosslink (ICL) repair involves proteins whose mutation results in the disorder Fanconi anaemia: here gene knockdown studies in mice show that the absence of HELQ, a protein previously implicated in ICL repair, compromises germ cell development and results in tumour predisposition due to defective recombination at damaged replication forks.

Suggested Citation

  • Carrie A. Adelman & Rafal L. Lolo & Nicolai J. Birkbak & Olga Murina & Kenichiro Matsuzaki & Zuzana Horejsi & Kalindi Parmar & Valérie Borel & J. Mark Skehel & Gordon Stamp & Alan D’Andrea & Alessandr, 2013. "HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis," Nature, Nature, vol. 502(7471), pages 381-384, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7471:d:10.1038_nature12565
    DOI: 10.1038/nature12565
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    Cited by:

    1. Jiexiang Zhao & Ping Lu & Cong Wan & Yaping Huang & Manman Cui & Xinyan Yang & Yuqiong Hu & Yi Zheng & Ji Dong & Mei Wang & Shu Zhang & Zhaoting Liu & Shuhui Bian & Xiaoman Wang & Rui Wang & Shaofang , 2021. "Cell-fate transition and determination analysis of mouse male germ cells throughout development," Nature Communications, Nature, vol. 12(1), pages 1-20, December.
    2. Jessica D. Tischler & Hiroshi Tsuchida & Rosevalentine Bosire & Tommy T. Oda & Ana Park & Richard O. Adeyemi, 2024. "FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. J. A. Kamp & B. B. L. G. Lemmens & R. J. Romeijn & S. C. Changoer & R. Schendel & M. Tijsterman, 2021. "Helicase Q promotes homology-driven DNA double-strand break repair and prevents tandem duplications," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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