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A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

Author

Listed:
  • Lara M. Mangravite

    (Sage Bionetworks, 1100 Fairview Avenue North)

  • Barbara E. Engelhardt

    (University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
    Present addresses: Biostatistics and Bioinformatics Department and Department of Statistical Science, Duke University, Durham, North Carolina, USA (B.E.E.); Adaptive Biotechnologies, Seattle, Washington, USA (M.J.R.).)

  • Marisa W. Medina

    (Children’s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way)

  • Joshua D. Smith

    (University of Washington, 3720 15th Avenue Northeast, Seattle, Washington 98195, USA)

  • Christopher D. Brown

    (University of Pennsylvania, 415 Curie Boulevard, Philadelphia, Pennsylvania 19103, USA)

  • Daniel I. Chasman

    (Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, 900 Commonwealth Drive, Boston, Massachusetts 02115, USA)

  • Brigham H. Mecham

    (Sage Bionetworks, 1100 Fairview Avenue North)

  • Bryan Howie

    (University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA)

  • Heejung Shim

    (University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA)

  • Devesh Naidoo

    (Children’s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way)

  • QiPing Feng

    (Vanderbilt University Medical Center, 23rd Avenue South)

  • Mark J. Rieder

    (University of Washington, 3720 15th Avenue Northeast, Seattle, Washington 98195, USA
    Present addresses: Biostatistics and Bioinformatics Department and Department of Statistical Science, Duke University, Durham, North Carolina, USA (B.E.E.); Adaptive Biotechnologies, Seattle, Washington, USA (M.J.R.).)

  • Yii.-Der I. Chen

    (Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, 1124 West Carson Street, Torrance, California 90502, USA)

  • Jerome I. Rotter

    (Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, 1124 West Carson Street, Torrance, California 90502, USA)

  • Paul M. Ridker

    (Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, 900 Commonwealth Drive, Boston, Massachusetts 02115, USA)

  • Jemma C. Hopewell

    (Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK)

  • Sarah Parish

    (Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK)

  • Jane Armitage

    (Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK)

  • Rory Collins

    (Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK)

  • Russell A. Wilke

    (Vanderbilt University Medical Center, 23rd Avenue South)

  • Deborah A. Nickerson

    (University of Washington, 3720 15th Avenue Northeast, Seattle, Washington 98195, USA)

  • Matthew Stephens

    (University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
    Eckhart Hall, 5734 South University Avenue, University of Chicago)

  • Ronald M. Krauss

    (Children’s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way)

Abstract

Exploration of the interacting effect of statin exposure and genetic variation on gene expression identifies a cis-eQTL that is differentially associated with expression of the GATM gene, which encodes a rate-limiting enzyme involved in creatine synthesis, and that is associated with incidence of statin-induced myopathy, the major adverse effect of statin treatment.

Suggested Citation

  • Lara M. Mangravite & Barbara E. Engelhardt & Marisa W. Medina & Joshua D. Smith & Christopher D. Brown & Daniel I. Chasman & Brigham H. Mecham & Bryan Howie & Heejung Shim & Devesh Naidoo & QiPing Fen, 2013. "A statin-dependent QTL for GATM expression is associated with statin-induced myopathy," Nature, Nature, vol. 502(7471), pages 377-380, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7471:d:10.1038_nature12508
    DOI: 10.1038/nature12508
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    Cited by:

    1. Justyna A. Resztak & Jane Choe & Shreya Nirmalan & Julong Wei & Julian Bruinsma & Russell Houpt & Adnan Alazizi & Henriette E. Mair-Meijers & Xiaoquan Wen & Richard B. Slatcher & Samuele Zilioli & Rog, 2023. "Analysis of transcriptional changes in the immune system associated with pubertal development in a longitudinal cohort of children with asthma," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. James S Floyd & Katarzyna M Bloch & Jennifer A Brody & Cyrielle Maroteau & Moneeza K Siddiqui & Richard Gregory & Daniel F Carr & Mariam Molokhia & Xiaoming Liu & Joshua C Bis & Ammar Ahmed & Xuan Liu, 2019. "Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-13, June.
    3. Heejung Shim & Daniel I Chasman & Joshua D Smith & Samia Mora & Paul M Ridker & Deborah A Nickerson & Ronald M Krauss & Matthew Stephens, 2015. "A Multivariate Genome-Wide Association Analysis of 10 LDL Subfractions, and Their Response to Statin Treatment, in 1868 Caucasians," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-20, April.

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